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Literature summary extracted from

  • Nicola, G.; Smith, C.A.; Lucumi, E.; Kuo, M.R.; Karagyozov, L.; Fidock, D.A.; Sacchettini, J.C.; Abagyan, R.
    Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening (2007), Biochem. Biophys. Res. Commun., 358, 686-691.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9 expressed in Escherichia coli BL21(DE3) Codon+-RIL cells Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 (2E)-3-pyren-1-yl-1-[4-(1H-triaziren-1-yl)phenyl]prop-2-en-1-one 45% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 1-(4-bromophenyl)-3-(dibenzo[b,d]furan-3-ylamino)propan-1-one 47% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 2,4-dichloro-N-(2-[[2-oxo-2-(phenylamino)ethyl]sulfanyl]-1,3-benzothiazol-6-yl)benzamide 49% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 2-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanyl]-N-(4-methylphenyl)acetamide 25% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 2-[[4-amino-5-(3,4-dichlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl]-N-naphthalen-2-ylacetamide 3% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 2-[[4-amino-5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl]-N-[4-bromo-2-(1-methylethyl)phenyl]acetamide 52% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 2-[[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]-N-(4-fluorophenyl)acetamide 20% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 3-[(4-methylcyclohexyl)sulfamoyl]-N-(4-methylphenyl)benzamide 49% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 3-[2-(3-fluoro-4-methoxyphenyl)-2-oxoethoxy]-6H-benzo[c]chromen-6-one 9% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 3-[2-(4-bromophenyl)-2-oxoethoxy]-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one 53% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 4-bromo-N-(4-chlorophenyl)-3-(phenylsulfamoyl)benzamide 46% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 4-bromo-N-[2-(3,4-dimethoxyphenyl)-1,3-benzoxazol-5-yl]benzamide 17% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 4-bromo-N-[4-(trifluoromethyl)phenyl]benzamide 49% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 N'-[(1E)-(5-bromo-2-hydroxyphenyl)methylidene]-4-(piperidin-1-ylsulfonyl)benzohydrazide 49% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 N'-[(1Z)-(5-chloro-2-hydroxyphenyl)methylidene]-4-(piperidin-1-ylsulfonyl)benzohydrazide 24% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 N-(4-bromophenyl)-2-chloro-5-[(4-methylphenyl)sulfamoyl]benzamide 41% residual activity at 0.05 mM Plasmodium falciparum
1.3.1.9 triclosan 0.2% residual activity at 0.05 mM Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.9 Ni-NTA affinity column chromatography Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonoyl-CoA + NADH
-
 Plasmodium falciparum butyryl-CoA + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl-ACP reductase
-
 Plasmodium falciparum
1.3.1.9 ENR
-
 Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NADH
-
 Plasmodium falciparum