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Literature summary extracted from

  • Cooper, A.J.; Pinto, J.T.; Krasnikov, B.F.; Niatsetskaya, Z.V.; Han, Q.; Li, J.; Vauzour, D.; Spencer, J.P.
    Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase (2008), Arch. Biochem. Biophys., 474, 72-81.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.64 Homo sapiens
-
 recombinant
-
4.4.1.13 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.13 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.64 5-S-L-cysteinyl-L-DOPA + 4-(methylsulfanyl)-2-oxobutanoate
-
 Homo sapiens ?
-
 ?
2.6.1.64 5-S-L-cysteinyldopamine + 4-(methylsulfanyl)-2-oxobutanoate transamination of 5 mM 5-S-Lcysteinyldopamine with 1 mM 4-(methylsulfanyl)-2-oxobutanoateat pH 7.4 is about 0.07% the rate at which the enzyme catalyzes transamination between 20 mM L-phenylalanine and 5 mM alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 L-3-(1-naphthyl)alanine + 4-(methylsulfanyl)-2-oxobutanoate about 0.2% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 L-3-(2-naphthyl)alanine + 4-(methylsulfanyl)-2-oxobutanoate about 0.5% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 L-DOPA + 4-(methylsulfanyl)-2-oxobutanoate about 0.02% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 L-kynurenine + 4-(methylsulfanyl)-2-oxobutanoate about 23.6% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 L-phenylalanine + 4-(methylsulfanyl)-2-oxobutanoate
-
 Homo sapiens ?
-
 ?
2.6.1.64 L-tyrosine + 4-(methylsulfanyl)-2-oxobutanoate about 9% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 additional information recombinant human glutamine transaminase K exhibits broad specificity both as an aminotransferase and as a cysteine S-conjugate beta-lyase Homo sapiens ?
-
 ?
2.6.1.64 phenylpyruvate + L-glutamine about 64% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 phenylpyruvate + L-leucine about 25% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 phenylpyruvate + L-methionine about 30% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + 4-(methylsulfanyl)-2-oxobutanoate about 63% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 S-(1,2-dichlorovinyl)-L-cysteine + 4-(methylsulfanyl)-2-oxobutanoate about 13% the rate exhibited with L-phenylalanine and alpha-oxo-gamma-methiolbutyrate Homo sapiens ?
-
 ?
2.6.1.64 Se-methyl-L-selenocysteine + 4-(methylsulfanyl)-2-oxobutanoate
-
 Homo sapiens ?
-
 ?
4.4.1.13 5-S-L-cysteinyldopamine slow beta-elimination reaction Homo sapiens pyruvate + ?
-
 ?
4.4.1.13 benzothiazolyl-L-cysteine
-
 Homo sapiens ?
-
 ?
4.4.1.13 beta-chloro-DL-alanine
-
 Homo sapiens ?
-
 ?
4.4.1.13 additional information beta-lyase reactions with S-(1,1,2,2-tetrafluoroethyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-cysteine, and Se-methyl-L-selenocysteine are more favorable than the GTK-catalyzed aminotransferase reactions with these amino acids Homo sapiens ?
-
 ?
4.4.1.13 additional information no reaction with 5-S-L-cysteinyl-L-DOPA Homo sapiens ?
-
 ?
4.4.1.13 RSH-CH2-CH(NH3+)COO- + H2O
-
 Homo sapiens RSH + NH3 + pyruvate
-
 ?
4.4.1.13 S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
 Homo sapiens NH3 + pyruvate + 1,1,2,2-tetrafluoroethanethiol
-
 ?
4.4.1.13 S-(1,2-dichlorovinyl)-L-cysteine
-
 Homo sapiens ?
-
 ?
4.4.1.13 Se-methyl-L-selenocysteine
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.64 glutamine transaminase K
-
 Homo sapiens
2.6.1.64 GTK
-
 Homo sapiens
4.4.1.13 beta-lyase
-
 Homo sapiens
4.4.1.13 glutamine transaminase K exhibits broad specificity both as an aminotransferase and as a cysteine S-conjugate beta-lyase Homo sapiens
4.4.1.13 GTK
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.64 9
-
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.13 pyridoxal 5'-phosphate
-
 Homo sapiens