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Literature summary extracted from

  • Hwang, S.H.; Tsai, H.J.; Liu, J.Y.; Morisseau, C.; Hammock, B.D.
    Orally bioavailable potent soluble epoxide hydrolase inhibitors (2007), J. Med. Chem., 50, 3825-3840.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.3.2.10 produced in a baculovirus expression system Mus musculus
3.3.2.10 produced in a baculovirus expression system Rattus norvegicus
3.3.2.10 produced in a baculovirus expression system Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.10 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Canis lupus
3.3.2.10 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Felis catus
3.3.2.10 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Homo sapiens
3.3.2.10 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Mesocricetus auratus
3.3.2.10 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Mus musculus
3.3.2.10 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Rattus norvegicus
3.3.2.10 APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Canis lupus
3.3.2.10 APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Felis catus
3.3.2.10 APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Homo sapiens
3.3.2.10 APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Mesocricetus auratus
3.3.2.10 APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Mus musculus
3.3.2.10 APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Rattus norvegicus
3.3.2.10 AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Canis lupus
3.3.2.10 AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Felis catus
3.3.2.10 AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Homo sapiens
3.3.2.10 AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Mesocricetus auratus
3.3.2.10 AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Mus musculus
3.3.2.10 AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Rattus norvegicus
3.3.2.10 cis-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
-
Homo sapiens
3.3.2.10 cis-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 cis-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 cis-1-adamantan-1-yl-3-[4-(4-bromophenoxy)cyclohexyl]urea
-
Homo sapiens
3.3.2.10 cis-1-adamantan-1-yl-3-[4-(4-fluorophenoxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 cis-1-adamantan-1-yl-3-[4-(4-methoxyphenoxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 cis-1-adamantan-1-yl-3-[4-(4-nitrophenoxy)cyclohexyl]urea
-
Homo sapiens
3.3.2.10 cis-3-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
Homo sapiens
3.3.2.10 cis-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)-benzoic acid
-
Homo sapiens
3.3.2.10 trans-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
-
Homo sapiens
3.3.2.10 trans-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 trans-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 trans-1-adamantan-1-yl-3-[4-(2-methylbenzyloxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 trans-1-adamantan-1-yl-3-[4-(3,5-difluorophenoxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 trans-1-adamantan-1-yl-3-[4-(4-bromobenzyloxy)cyclohexyl]-urea
-
Homo sapiens
3.3.2.10 trans-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)benzoic acid
-
Homo sapiens
3.3.2.10 trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
Canis lupus
3.3.2.10 trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
Felis catus
3.3.2.10 trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
Homo sapiens
3.3.2.10 trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
Mesocricetus auratus
3.3.2.10 trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
Mus musculus
3.3.2.10 trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Canis lupus
-
-
-
3.3.2.10 Felis catus
-
-
-
3.3.2.10 Homo sapiens P34913
-
-
3.3.2.10 Mesocricetus auratus
-
-
-
3.3.2.10 Mus musculus
-
-
-
3.3.2.10 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.10 4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
-
Homo sapiens ?
-
?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.10 0.00000055
-
pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(4-methoxyphenoxy)cyclohexyl]-urea
3.3.2.10 0.0000006
-
pH 7.4, 30°C Homo sapiens cis-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)-benzoic acid
3.3.2.10 0.00000072
-
pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(4-nitrophenoxy)cyclohexyl]urea
3.3.2.10 0.0000009
-
pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
3.3.2.10 0.0000009
-
pH 7.4, 30°C Homo sapiens trans-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)benzoic acid
3.3.2.10 0.000001
-
pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(4-fluorophenoxy)cyclohexyl]-urea
3.3.2.10 0.000001
-
pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(3,5-difluorophenoxy)cyclohexyl]-urea
3.3.2.10 0.000001
-
pH 7.5, 30°C Canis lupus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
3.3.2.10 0.0000011
-
pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
3.3.2.10 0.0000013
-
pH 7.4, 30°C Homo sapiens trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
3.3.2.10 0.0000013
-
pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(4-bromophenoxy)cyclohexyl]urea
3.3.2.10 0.0000015
-
pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
3.3.2.10 0.0000016
-
pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(2-methylbenzyloxy)cyclohexyl]-urea
3.3.2.10 0.0000017
-
pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
3.3.2.10 0.0000017
-
pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
3.3.2.10 0.0000017
-
pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
3.3.2.10 0.0000017
-
pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(4-bromobenzyloxy)cyclohexyl]-urea
3.3.2.10 0.0000019
-
pH 7.4, 30°C Homo sapiens cis-3-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
3.3.2.10 0.000002
-
pH 7.5, 30°C Mesocricetus auratus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
3.3.2.10 0.000002
-
pH 7.5, 30°C Mesocricetus auratus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
3.3.2.10 0.000002
-
pH 7.5, 30°C Mesocricetus auratus APAU
3.3.2.10 0.000003
-
pH 7.4, 30°C Homo sapiens AUDA
3.3.2.10 0.000003
-
pH 7.5, 30°C Felis catus AUDA
3.3.2.10 0.000003
-
pH 7.5, 30°C Canis lupus AUDA
3.3.2.10 0.000003
-
pH 7.5, 30°C Mus musculus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
3.3.2.10 0.000005
-
pH 7.5, 30°C Mesocricetus auratus AUDA
3.3.2.10 0.000005
-
pH 7.5, 30°C Rattus norvegicus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
3.3.2.10 0.000006
-
pH 7.5, 30°C Felis catus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
3.3.2.10 0.000006
-
pH 7.5, 30°C Rattus norvegicus APAU
3.3.2.10 0.000008
-
pH 7.5, 30°C Mus musculus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
3.3.2.10 0.000008
-
pH 7.5, 30°C Rattus norvegicus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
3.3.2.10 0.000009
-
pH 7.5, 30°C Mus musculus APAU
3.3.2.10 0.00001
-
pH 7.5, 30°C Mus musculus AUDA
3.3.2.10 0.000011
-
pH 7.5, 30°C Rattus norvegicus AUDA
3.3.2.10 0.000014
-
pH 7.4, 30°C Homo sapiens 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
3.3.2.10 0.000015
-
pH 7.4, 30°C Homo sapiens APAU
3.3.2.10 0.000027
-
pH 7.5, 30°C Felis catus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
3.3.2.10 0.000086
-
pH 7.5, 30°C Canis lupus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
3.3.2.10 0.00045
-
pH 7.5, 30°C Felis catus APAU
3.3.2.10 0.0005
-
pH 7.5, 30°C Canis lupus APAU