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Literature summary extracted from

  • Kushiro, T.; Shibuya, M.; Masuda, K.; Ebizuka, Y.
    Mutational studies on triterpene synthases: engineering lupeol synthase into beta-amyrin synthase (2000), J. Am. Chem. Soc., 122, 6816-6824.
No PubMed abstract available

Protein Variants

EC Number Protein Variants Comment Organism
5.4.99.39 C262S mutation in region responsible for product differentiation. Like wild-type, mutant produces beta-amyrin as sole product Panax ginseng
5.4.99.39 M258I/W259L mutation in region responsible for product differentiation. Mutant produces 40.5% beta-amyrin, 53.4% lupeol, 3.6% butyrospermol and 2.5% germanicol Panax ginseng
5.4.99.39 W259L mutation in region responsible for product differentiation. Mutant produces 30.3% beta-amyrin, 54.6% lupeol, 3.6% butyrospermol and 3.4% germanicol Panax ginseng
5.4.99.39 Y261H mutation in region responsible for product differentiation. Mutant produces 2.4% lupeol, 13.6% germanicol and 84% of dammara-18(E),21-dien-3beta-ol, dammara-18(Z),21-dien-3beta-ol and dammara-18(28),21-dien-3beta-ol Panax ginseng
5.4.99.41 L256A mutation in region responsible for product differentiation. Mutant produces 3.8% beta-amyrin, 69.5% lupeol, 10% butyrospermol and 13.5% of dammara-18(E),21-dien-3beta-ol, dammara-18(Z),21-dien-3beta-ol and dammara-18(28),21-dien-3beta-ol Olea europaea
5.4.99.41 L256F mutation in region responsible for product differentiation. Mutant produces 9.8% beta-amyrin, 69.7% lupeol, 17.9% butyrospermol Olea europaea
5.4.99.41 L256H mutation in region responsible for product differentiation. Mutant produces 3.8% beta-amyrin, 69.5% lupeol, 10% butyrospermol and 13.5% of dammara-18(E),21-dien-3beta-ol, dammara-18(Z),21-dien-3beta-ol and dammara-18(28),21-dien-3beta-ol Olea europaea
5.4.99.41 L256W mutation in region responsible for product differentiation. Mutant produces 74.8% beta-amyrin, 6.9% lupeol, 9.9% butyrospermol and 8.4% germanicol Olea europaea
5.4.99.41 L256Y mutation in region responsible for product differentiation. Mutant produces 1.6% beta-amyrin, 54.8% lupeol, 22.7% butyrospermol and 18.7% of dammara-18(E),21-dien-3beta-ol, dammara-18(Z),21-dien-3beta-ol and dammara-18(28),21-dien-3beta-ol Olea europaea
5.4.99.41 Y258H mutation in region responsible for product differentiation. Mutant produces 43.6% lupeol, 6.2% butyrospermol and 42.4% of dammara-18(E),21-dien-3beta-ol, dammara-18(Z),21-dien-3beta-ol and dammara-18(28),21-dien-3beta-ol Olea europaea

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.39 Panax ginseng
-
-
-
5.4.99.41 Olea europaea
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.39 2,3-oxidosqualene
-
Panax ginseng beta-amyrin
-
?
5.4.99.41 2,3-oxidosqualene
-
Olea europaea lupeol
-
?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.41 OEW
-
Olea europaea