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Literature summary extracted from

  • Tsruya, R.; Wojtalla, A.; Carmon, S.; Yogev, S.; Reich, A.; Bibi, E.; Merdes, G.; Schejter, E.; Shilo, B.Z.
    Rhomboid cleaves Star to regulate the levels of secreted Spitz (2007), EMBO J., 26, 1211-1220.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.105 endoplasmic reticulum membrane
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 Drosophila melanogaster 5789
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3.4.21.105 endosome membranes of the late endosome compartment Drosophila melanogaster 5768
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3.4.21.105 membrane Rhomboid is an intramembrane protein Drosophila melanogaster 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.105 chaperone Star + H2O Drosophila melanogaster cleavage of Star within its transmembrane domain both in cell culture and in flies, the enzyme is involved in regulation of levels of Spitz, the major Drosophila EGF receptor ligand, mechanism for modulating the activity of Star, thereby influencing the levels of active Spitz ligand, intracellular trafficking of Spitz isimpaired by Rhomboid-dependent cleavage of Star, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.105 Drosophila melanogaster
-
-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.105 chaperone Star + H2O cleavage of Star within its transmembrane domain both in cell culture and in flies, the enzyme is involved in regulation of levels of Spitz, the major Drosophila EGF receptor ligand, mechanism for modulating the activity of Star, thereby influencing the levels of active Spitz ligand, intracellular trafficking of Spitz isimpaired by Rhomboid-dependent cleavage of Star, overview Drosophila melanogaster ?
-
 ?
3.4.21.105 chaperone Star + H2O a type II transmembrane protein, cleavage in the transmembrane sequence 298IVYMoxDTTEIRHQQF311 Drosophila melanogaster ?
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 ?
3.4.21.105 additional information Rhomboid cleaves both type I and type II transmembrane proteins Drosophila melanogaster ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.105 Rhomboid
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 Drosophila melanogaster
3.4.21.105 rhomboid-1
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 Drosophila melanogaster