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Literature summary extracted from

  • Sutton, V.R.; Estella, E.; Li, C.; Chen, M.; Thomas, H.E.; Kay, T.W.; Trapani, J.A.
    A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death (2006), Transplantation, 81, 146-154.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.79 additional information cytotoxic granule-mediated death of both primary and transformed beta cells requires granzyme B. Early cell death is completely dependent on granzyme B. Death induced by granzyme B is dependent on cosecretion with perforin Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.79 additional information granzyme B deficient mice lack expression of linked granzyme-loci, due to accidental effects of the thymidine kinase enhancer integrated into the granzyme locus on mouse Chromosome 14 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.79 additional information to protect beta cells from allogeneic CTL attack, one needs to inhibit the perforin/granzyme and probably also the TNFalpha pathway. Granzyme B-dependent death of NIT-1 cells is not inhibited by Bcl-2 overexpression Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.79 Mus musculus
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 NOD/Lt, NOD/lpr, NOD.TNFR-/- and C57BL/mice, or strain 129(H-2b) backcrossed onto BL/6 for a minimum of 10 generations
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Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.79
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.79 cytotoxic T-lymphocyte cell line
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 Mus musculus
-