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Literature summary extracted from

  • Ammelburg, M.; Hartmann, M.D.; Djuranovic, S.; Alva, V.; Koretke, K.K.; Martin, J.; Sauer, G.; Truffault, V.; Zeth, K.; Lupas, A.N.; Coles, M.
    A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels (2007), Structure, 15, 1577-1590.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.161 Mj0056 has sequence properties intermediate between basal cradle-loop barrels and ATP-dependent riboflavin kinases. It is proposed that it represents an evolutionary bridge between the two groups of proteins Methanocaldococcus jannaschii
2.7.1.161 Mj0056-MgCDP and Mj0056-MgCDP-FMN, in complex with natural reaction products and, Mj0056-NaCDP-PO4, with inorganic phosphate bound in a similar position as the FMN phosphate Methanocaldococcus jannaschii
2.7.1.161 structures, Mj0056-MgCDP and Mj0056-MgCDP-FMN, in complex with natural reaction products and a third, Mj0056-NaCDP-PO4, with inorganic phosphate Methanocaldococcus jannaschii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.161 additional information
-
 Mj0056 has sequence properties intermediate between basal cradle-loop barrels and ATP-dependent riboflavin kinases. It is proposed that it represents an evolutionary bridge between the two groups of proteins Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.161 Methanocaldococcus jannaschii
-
-
-
2.7.1.161 Methanocaldococcus jannaschii Q60365
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.161 CTP + riboflavin utilizes CTP rather than ATP as the donor nucleotide Methanocaldococcus jannaschii CDP + riboflavin 5'-phosphate
-
 ?
2.7.1.161 CTP + riboflavin
-
 Methanocaldococcus jannaschii CDP + FMN
-
 ?
2.7.1.161 CTP + riboflavin at reaction temperatures of up to 85°C (the temperature of the natural habitat of Methanocaldococcus jannaschii) riboflavin is completely converted to FMN Methanocaldococcus jannaschii CDP + FMN
-
 ?
2.7.1.161 additional information ATP and GTP do not support the production of FMN at 85°C Methanocaldococcus jannaschii ?
-
 ?
2.7.1.161 UTP + riboflavin activity with UTP is at least one order of magnitude less efficient Methanocaldococcus jannaschii UDP + FMN
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.161 CTP-dependent riboflavin kinase
-
 Methanocaldococcus jannaschii
2.7.1.161 Methanocaldococcus jannaschii Mj0056
-
 Methanocaldococcus jannaschii
2.7.1.161 MJ0056
-
 Methanocaldococcus jannaschii