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Literature summary extracted from

  • Feng, L.; Yan, H.; Wu, Z.; Yan, N.; Wang, Z.; Jeffrey, P.D.; Shi, Y.
    Structure of a site-2 protease family intramembrane metalloprotease (2007), Science, 318, 1608-1612.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.85 expressed in Escherichia coli Methanocaldococcus jannaschii

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.85 D148A mutant exhibits markedly compromised protease activity Methanocaldococcus jannaschii
3.4.24.85 E55A mutant exhibits markedly compromised protease activity Methanocaldococcus jannaschii
3.4.24.85 H54A mutant exhibits markedly compromised protease activity Methanocaldococcus jannaschii
3.4.24.85 H54A/D148A mutant exhibits markedly compromised protease activity Methanocaldococcus jannaschii
3.4.24.85 H58A mutant exhibits markedly compromised protease activity Methanocaldococcus jannaschii

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.85 1,10-phenanthroline 1,10-phenanthroline specifically inhibits substrate cleavage in a concentration-dependent manner Methanocaldococcus jannaschii

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.85 Zn2+ dependent Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.85 Methanocaldococcus jannaschii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.85 SREBP NH2-522 fragment + H2O
-
 Methanocaldococcus jannaschii NH2-484 fragment + 38 aa fragment
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.85 S2P
-
 Methanocaldococcus jannaschii
3.4.24.85 site-2 protease
-
 Methanocaldococcus jannaschii