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Literature summary extracted from
- Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II (2007), Proc. Natl. Acad. Sci. USA, 104, 4840-4845.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.6.2.2 | N-terminal hexahistidine tag, expressed in yeast | Drosophila melanogaster |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.2.2 | Drosophila melanogaster | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 5.6.2.2 | ATP-dependent breakage, passage and rejoining of double-stranded DNA | the DNA substrate undergoes an enzyme-mediated transition between a closed and open state in the presence of ATP. Transition has comparable rate constants for both the opening and closing reaction during steady-state ATP hydrolysis, with an apparent equilibrium constant near unity. The open and closed states do not interconvert at a measurable rate | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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