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Literature summary extracted from

  • Bitto, E.; Bingman, C.A.; Wesenberg, G.E.; McCoy, J.G.; Phillips, G.N.
    Structure of aspartoacylase, the brain enzyme impaired in Canavan disease (2007), Proc. Natl. Acad. Sci. USA, 104, 456-461.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.15 expression in Escherichia coli Rattus norvegicus
3.5.1.15 expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.1.15 resolution 1.8 angstrom Rattus norvegicus
3.5.1.15 resolution 2.8 Angstrom Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.15 Zn2+ necessary for activity Rattus norvegicus
3.5.1.15 Zn2+ necessary for activity, coordinated by residues His-21, Glu-24, and His-116 and a phosphate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.15 N-acetyl-L-aspartate + H2O Rattus norvegicus deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease aspartate + acetate
-
 ?
3.5.1.15 N-acetyl-L-aspartate + H2O Homo sapiens deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease aspartate + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.15 Homo sapiens P45381
-
-
3.5.1.15 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.15
-
 Rattus norvegicus
3.5.1.15
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.15 brain
-
 Rattus norvegicus
-
3.5.1.15 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.15 N-acetyl-L-aspartate + H2O deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease Rattus norvegicus aspartate + acetate
-
 ?
3.5.1.15 N-acetyl-L-aspartate + H2O deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease Homo sapiens aspartate + acetate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.1.15 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.5.1.15 aminoacylase 2
-
 Rattus norvegicus
3.5.1.15 aminoacylase 2
-
 Homo sapiens
3.5.1.15 ASPA
-
 Rattus norvegicus
3.5.1.15 ASPA
-
 Homo sapiens
3.5.1.15 Aspartoacylase
-
 Rattus norvegicus
3.5.1.15 Aspartoacylase
-
 Homo sapiens