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Literature summary extracted from

  • Ingle, R.A.; Mugford, S.T.; Rees, J.D.; Campbell, M.M.; Smith, J.A.
    Constitutively high expression of the histidine biosynthetic pathway contributes to nickel tolerance in hyperaccumulator plants (2005), Plant Cell, 17, 2089-2106.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.17 overexpression of an Alyssum lesbiacum ATP-PRT cDNA in transgenic Arabidopsis thaliana increases the pool of free His up to 15fold in shoot tissue, without affecting the concentration of any other amino acid. His-overproducing lines also display elevated tolerance to Ni but do not exhibit increased Ni concentrations in either xylem sap or shoot tissue, suggesting that additional factors are necessary to recapitulate the complete hyperaccumulator phenotype Alyssum montanum
2.4.2.17 overexpression of an Alyssum lesbiacum ATP-PRT cDNA in transgenic Arabidopsis thaliana increases the pool of free His up to 15fold in shoot tissue, without affecting the concentration of any other amino acid. His-overproducing lines also display elevated tolerance to Ni but do not exhibit increased Ni concentrations in either xylem sap or shoot tissue, suggesting that additional factors are necessary to recapitulate the complete hyperaccumulator phenotype Odontarrhena lesbiaca
2.4.2.17 overexpression of an Alyssum lesbiacum ATP-PRT cDNA in transgenic Arabidopsis thaliana increases the pool of free His up to 15fold in shoot tissue, without affecting the concentration of any other amino acid. His-overproducing lines also display elevated tolerance to Ni but do not exhibit increased Ni concentrations in either xylem sap or shoot tissue, suggesting that additional factors are necessary to recapitulate the complete hyperaccumulator phenotype Odontarrhena serpyllifolia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate Odontarrhena lesbiaca first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 ?
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate Alyssum montanum first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 ?
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate Odontarrhena serpyllifolia first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.17 Alyssum montanum Q56US5
-
-
2.4.2.17 Odontarrhena lesbiaca Q56UT3
-
-
2.4.2.17 Odontarrhena lesbiaca Q56UT2
-
-
2.4.2.17 Odontarrhena serpyllifolia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.17 root transcript levels is constitutively higher in Alyssum lesbiacum (a plant that hyperaccumulates Ni and exhibits an exceptional degree of Ni tolerance) than in the congeneric nonaccumulator Alyssum montanum, transcript levels in the weak hyperaccumulator Alyssum serpyllifolium is intermediate Odontarrhena lesbiaca
-
2.4.2.17 root transcript levels is constitutively higher in Alyssum lesbiacum (a plant that hyperaccumulates Ni and exhibits an exceptional degree of Ni tolerance) than in the congeneric nonaccumulator Alyssum montanum, transcript levels in the weak hyperaccumulator Alyssum serpyllifolium is intermediate Alyssum montanum
-
2.4.2.17 root transcript levels is constitutively higher in Alyssum lesbiacum (a plant that hyperaccumulates Ni and exhibits an exceptional degree of Ni tolerance) than in the congeneric nonaccumulator Alyssum montanum, transcript levels in the weak hyperaccumulator Alyssum serpyllifolium is intermediate Odontarrhena serpyllifolia
-
2.4.2.17 shoot transcript levels is constitutively higher in Alyssum lesbiacum (a plant that hyperaccumulates Ni and exhibits an exceptional degree of Ni tolerance) than in the congeneric nonaccumulator Alyssum montanum, transcript levels in the weak hyperaccumulator Alyssum serpyllifolium is intermediate Odontarrhena lesbiaca
-
2.4.2.17 shoot transcript levels is constitutively higher in Alyssum lesbiacum (a plant that hyperaccumulates Ni and exhibits an exceptional degree of Ni tolerance) than in the congeneric nonaccumulator Alyssum montanum, transcript levels in the weak hyperaccumulator Alyssum serpyllifolium is intermediate Alyssum montanum
-
2.4.2.17 shoot transcript levels is constitutively higher in Alyssum lesbiacum (a plant that hyperaccumulates Ni and exhibits an exceptional degree of Ni tolerance) than in the congeneric nonaccumulator Alyssum montanum, transcript levels in the weak hyperaccumulator Alyssum serpyllifolium is intermediate Odontarrhena serpyllifolia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species Odontarrhena lesbiaca 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 ?
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species Alyssum montanum 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 ?
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species Odontarrhena serpyllifolia 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.17 ATP-PRT
-
 Odontarrhena serpyllifolia
2.4.2.17 ATP-PRT1
-
 Odontarrhena lesbiaca
2.4.2.17 ATP-PRT1
-
 Alyssum montanum
2.4.2.17 ATP-PRT2
-
 Odontarrhena lesbiaca