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Literature summary extracted from

  • Korbsrisate, S.; Tomaras, A.P.; Damnin, S.; Ckumdee, J.; Srinon, V.; Lengwehasatit, I.; Vasil, M.L.; Suparak, S.
    Characterization of two distinct phospholipase C enzymes from Burkholderia pseudomallei (2007), Microbiology, 153, 1907-1915.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.3 additional information isoform Plc-1 inactivation mutant shows decreased extracellular enzyme activity. Plc-1 has no effect on plaque-forming efficinecy, but increases the efficiency of isoform Plc-2 to form plaques Burkholderia pseudomallei
3.1.4.3 more | isoform Plc-2 inactivation mutant shows decreased extracellular enzyme activity. Plc-2 is involved in plaque formationand has a significant role in host cell cytotoxicity Burkholderia pseudomallei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.3 extracellular
-
 Burkholderia pseudomallei
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.3 77000
-
 x * 77000, calculated Burkholderia pseudomallei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.3 additional information Burkholderia pseudomallei enzyme is not haemolytic for human erythrocytes and not involved in multinucleated giant cell formation or induction of apoptotic cell death ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.3 Burkholderia pseudomallei Q9RGS8 isoform Plc-1
-
3.1.4.3 Burkholderia pseudomallei Q9RGS8 isoform Plc-2
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.3 proteolytic modification sequence shows a mature polypeptide of 700 amino acids plus a signal peptide of 34 amino acids Burkholderia pseudomallei
3.1.4.3 proteolytic modification sequence shows a mature polypeptide of 705 amino acids plus a signal peptide of 35 amino acids Burkholderia pseudomallei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.3 additional information enzyme is not haemolytic for human erythrocytes and not involved in multinucleated giant cell formation or induction of apoptotic cell death Burkholderia pseudomallei ?
-
 ?
3.1.4.3 phosphatidylcholine + H2O
-
 Burkholderia pseudomallei 1,2-diacylglycerol + phosphorylcholine
-
 ?
3.1.4.3 sphingomyelin + H2O
-
 Burkholderia pseudomallei ceramide + phosphorylcholine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.3 ? x * 77000, calculated Burkholderia pseudomallei

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.1.4.3 Burkholderia pseudomallei calculated
-
 6
3.1.4.3 Burkholderia pseudomallei calculated
-
 6.2