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Literature summary extracted from

  • Tan, K.; Li, H.; Zhang, R.; Gu, M.; Clancy, S.T.; Joachimiak, A.
    Structures of open (R) and close (T) states of prephenate dehydratase (PDT)-implication of allosteric regulation by L-phenylalanine (2007), J. Struct. Biol., 162, 94-107.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.51 crystal structures of prephenate dehydratase in a relaxed (R) state Staphylococcus aureus
4.2.1.51 crystal structures of prephenate dehydratase in a tense (T) state Chlorobaculum tepidum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.51 prephenate Staphylococcus aureus converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis phenylpyruvate + H2O + CO2
-
 ?
4.2.1.51 prephenate Chlorobaculum tepidum converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis phenylpyruvate + H2O + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.51 Chlorobaculum tepidum
-
-
-
4.2.1.51 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.51 prephenate converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis Staphylococcus aureus phenylpyruvate + H2O + CO2
-
 ?
4.2.1.51 prephenate converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis Chlorobaculum tepidum phenylpyruvate + H2O + CO2
-
 ?
4.2.1.51 prephenate at the interface two ACT regulatory domains create two highly conserved pockets. Upon binding of the L-Phe inside the pockets, PDT transits from an open to a closed conformation Staphylococcus aureus phenylpyruvate + H2O + CO2
-
 ?
4.2.1.51 prephenate at the interface two ACT regulatory domains create two highly conserved pockets. Upon binding of the L-Phe inside the pockets, PDT transits from an open to a closed conformation Chlorobaculum tepidum phenylpyruvate + H2O + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.51 tetramer
-
 Staphylococcus aureus
4.2.1.51 tetramer in crystal and solution Chlorobaculum tepidum

Synonyms

EC Number Synonyms Comment Organism
4.2.1.51 Ct-PDT
-
 Chlorobaculum tepidum
4.2.1.51 Sa-PDT
-
 Staphylococcus aureus