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Literature summary extracted from

  • Mattick, P.; Parrington, J.; Odia, E.; Simpson, A.; Collins, T.; Terrar, D.
    Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current (2007), J. Physiol., 582, 1195-1203.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 forskolin actions of Ca2+ chelator BAPTA are overcome by exposure to 0.001 mM forskolin, a direct stimulator of AC1, to restore cAMP levels Cavia porcellus

Application

EC Number Application Comment Organism
4.6.1.1 additional information Ca2+-stimulated AC regulates If via cAMP, modulation of the If pacemaker current Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 BAPTA inhibition of Ca2+-stimulated AC, buffers cytosolic Ca2+ and shifts activation in the hyperpolarizing direction, so that MDL 12330A has little or no further effect Cavia porcellus
4.6.1.1 MDL 12330A inhibitor of AC1 activity, shifts activation in the hyperpolarizing direction. Buffering cytosolic Ca2+ with the Ca2+ chelator BAPTA shifts activation in the hyperpolarizing direction, so that MDL 12330A has little or no further effect Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 cytosol AC8 Cavia porcellus 5829
-
4.6.1.1 plasma membrane AC1 Cavia porcellus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Ca2+
-
 Cavia porcellus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.6.1.1 125000
-
 immunoblotting, AC1 Cavia porcellus
4.6.1.1 140000
-
 immunoblotting, AC8 and AC5/6 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 atrium AC1 preferentially expressed in sino-atrial node cells, present as mRNA and as protein, AC5 present, AC8 absent Cavia porcellus
-
4.6.1.1 heart
-
 Cavia porcellus
-
4.6.1.1 hippocampus AC8 Cavia porcellus
-
4.6.1.1 additional information AC5 present and AC1 and AC8 absent in ventricular muscle, AC8 absent from cerebellum Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Cavia porcellus 3',5'-cAMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 AC1
-
 Cavia porcellus
4.6.1.1 AC5
-
 Cavia porcellus
4.6.1.1 AC8
-
 Cavia porcellus