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Literature summary extracted from

  • Hepp, R.; Tricoire, L.; Hu, E.; Gervasi, N.; Paupardin-Tritsch, D.; Lambolez, B.; Vincent, P.
    Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living thalamic neurons (2007), J. Neurochem., 102, 1875-1886.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 BAY60-7550 inhibition of isoform PDE2, results in increase in basal cGMP levels after application to thalamic neurons Mus musculus
3.1.4.17 erythro-9-(2-hydroxy-3-nonyl)adenine inhibition of isoform PDE2, results in increase in basal cGMP levels after application to thalamic neurons Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.17 additional information Mus musculus isoform PDE2 regulates the basal cGMP concentration in thalamic neuron ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Mus musculus Q01065
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 brain
-
 Mus musculus
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3.1.4.17 neuron living thalamic neurons, expression of enzyme isoforms PDE1, PDE2, PDE9, and PDE10 Mus musculus
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3.1.4.17 thalamus living thalamic neurons, expression of enzyme isoforms PDE1, PDE2, PDE9, and PDE10 Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 additional information isoform PDE2 regulates the basal cGMP concentration in thalamic neuron Mus musculus ?
-
 ?