Literature summary extracted from
Inada, M.; Matsumoto, C.; Uematsu, S.; Akira, S.; Miyaura, C.
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation (2006), J. Immunol., 177, 1879-1885.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
5.3.99.3 |
lipopolysaccharide |
lipopolysaccharide binds to receptor TLR4 on osteoblasts that directly induces isoform mPGES-1 expression for prostaglandin E2 synthesis, leading to subsequent bone resorption |
Mus musculus |
|
Application
EC Number |
Application |
Comment |
Organism |
---|
5.3.99.3 |
medicine |
use of isoform mPGES-1 as a target for the treatment of inflammatory bone disease |
Mus musculus |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
5.3.99.3 |
additional information |
isoform mPGES-1 knockout mice. Contrary to wild-type, in knock-out animals no prostaglandin E2 production is found in osteoblast after administration of LPS. While in wild-type, LPS reduces the bone volume in femur associated with an increased number of osteoclasts, this loss is reduced in knock-out mice. LPS induces the loss of alveolar bone in wild-type, but not in the mutants |
Mus musculus |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
5.3.99.3 |
Mus musculus |
- |
isoform mPGES-1 |
- |