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Literature summary extracted from

  • Pedone, E.; Searle, F.; Brocchini, S.
    Diethylstilbestrol glutamate as a potential substrate for ADEPT (2006), J. Drug Target., 14, 437-443.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.17.11 medicine potential use in antibody directed enzyme prodrug therapy (ADEPT) Pseudomonas sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.11 diethylstilbestrol-glutamate + H2O Pseudomonas sp. the water soluble substrate can be used as a prodrug that is hydrolyzed to yield the active drug in an antibody directed enzyme prodrug therapy diethylstilbestrol + L-glutamate
-
 ?
3.4.17.11 additional information Pseudomonas sp. specifically cleaves terminal glutamic acid amines ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.11 Pseudomonas sp.
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.11 diethylstilbestrol-glutamate + H2O
-
 Pseudomonas sp. diethylstilbestrol + L-glutamate
-
 ?
3.4.17.11 diethylstilbestrol-glutamate + H2O the water soluble substrate can be used as a prodrug that is hydrolyzed to yield the active drug in an antibody directed enzyme prodrug therapy Pseudomonas sp. diethylstilbestrol + L-glutamate
-
 ?
3.4.17.11 additional information specifically cleaves terminal glutamic acid amines Pseudomonas sp. ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.11 carboxypeptidase G2
-
 Pseudomonas sp.
3.4.17.11 CPG2
-
 Pseudomonas sp.

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.4.17.11 37
-
 assay at Pseudomonas sp.

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.17.11 7.3
-
 assay at Pseudomonas sp.