EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.22.71 | SrtB in complex with aryl (beta-amino)ethyl ketone inhibitors. Analysis of the three-dimensional structure ofBacillusanthracissortaseBwithandwithoutinhibitorprovidesinsights into the mechanism of inhibition | Bacillus anthracis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.70 | 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one | - |
Staphylococcus aureus | |
3.4.22.70 | 1-(4-bromophenyl)-3-(3-methylpiperidin-1-yl)propan-1-one | - |
Staphylococcus aureus | |
3.4.22.70 | 1-(4-chlorophenyl)-3-morpholin-4-ylpropan-1-one | - |
Staphylococcus aureus | |
3.4.22.70 | 1-(4-fluorophenyl)-3-morpholin-4-ylpropan-1-one | - |
Staphylococcus aureus | |
3.4.22.70 | 1-(4-methylphenyl)-3-morpholin-4-ylpropan-1-one | - |
Staphylococcus aureus | |
3.4.22.70 | 3-(dimethylamino)-1-(2-thienyl)propan-1-one | - |
Staphylococcus aureus | |
3.4.22.70 | 3-(dimethylamino)-1-(3-nitrophenyl)propan-1-one | - |
Staphylococcus aureus | |
3.4.22.70 | 3-anilino-1-(3-nitrophenyl)propan-1-one | - |
Staphylococcus aureus | |
3.4.22.70 | ethyl 4-[3-(4-bromophenyl)-3-oxopropyl]piperazine-1-carboxylate | - |
Staphylococcus aureus | |
3.4.22.70 | methyl 4-[3-(dimethylamino)propanoyl]benzenesulfinate | - |
Staphylococcus aureus | |
3.4.22.70 | additional information | aryl (beta-amino)ethyl ketones inhibit sortase enzymes. Inhibition of sortases occurs through an irreversible, covalent modification of their active site cysteine. Sortases specifically activate this class of molecules via beta-elimination, generating a reactive olefin intermediate that covalently modifies the cysteine thiol | Bacillus anthracis | |
3.4.22.70 | additional information | aryl (beta-amino)ethyl ketones inhibit sortase enzymes. Inhibition of sortases occurs through an irreversible, covalent modification of their active site cysteine. Sortases specifically activate this class of molecules via beta-elimination, generating a reactive olefin intermediate that covalently modifies the cysteine thiol | Staphylococcus aureus | |
3.4.22.71 | additional information | aryl (beta-amino)ethyl ketones inhibit sortase enzymes. Inhibition of sortases occurs through an irreversible, covalent modification of their active site cysteine. Sortases specifically activate this class of molecules via beta-elimination, generating a reactive olefin intermediate that covalently modifies the cysteine thiol | Bacillus anthracis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.70 | Bacillus anthracis | - |
- |
- |
3.4.22.70 | Staphylococcus aureus | - |
- |
- |
3.4.22.71 | Bacillus anthracis | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.70 | SrtA | - |
Staphylococcus aureus |
3.4.22.70 | SrtA | - |
Bacillus anthracis |
3.4.22.71 | SrtB | - |
Bacillus anthracis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.22.70 | 0.0472 | - |
- |
Staphylococcus aureus | 1-(4-fluorophenyl)-3-morpholin-4-ylpropan-1-one | |
3.4.22.70 | 0.0543 | - |
- |
Staphylococcus aureus | 3-(dimethylamino)-1-(3-nitrophenyl)propan-1-one | |
3.4.22.70 | 0.0548 | - |
- |
Staphylococcus aureus | 3-(dimethylamino)-1-(2-thienyl)propan-1-one | |
3.4.22.70 | 0.0569 | - |
- |
Staphylococcus aureus | 1-(4-bromophenyl)-3-(3-methylpiperidin-1-yl)propan-1-one | |
3.4.22.70 | 0.0569 | - |
- |
Staphylococcus aureus | 1-(4-methylphenyl)-3-morpholin-4-ylpropan-1-one | |
3.4.22.70 | 0.066 | - |
- |
Staphylococcus aureus | 3-anilino-1-(3-nitrophenyl)propan-1-one | |
3.4.22.70 | 0.0698 | - |
- |
Staphylococcus aureus | methyl 4-[3-(dimethylamino)propanoyl]benzenesulfinate | |
3.4.22.70 | 0.0802 | - |
- |
Staphylococcus aureus | ethyl 4-[3-(4-bromophenyl)-3-oxopropyl]piperazine-1-carboxylate | |
3.4.22.70 | 0.0837 | - |
- |
Staphylococcus aureus | 1-(4-bromophenyl)-3-(3-methylpiperidin-1-yl)propan-1-one | |
3.4.22.70 | 0.0844 | - |
- |
Staphylococcus aureus | 1-(4-chlorophenyl)-3-morpholin-4-ylpropan-1-one | |
3.4.22.70 | 0.0873 | - |
- |
Staphylococcus aureus | 3-anilino-1-(3-nitrophenyl)propan-1-one | |
3.4.22.70 | 0.0889 | - |
- |
Staphylococcus aureus | 1-(4-methylphenyl)-3-morpholin-4-ylpropan-1-one | |
3.4.22.70 | 0.0891 | - |
- |
Staphylococcus aureus | 1-(4-fluorophenyl)-3-morpholin-4-ylpropan-1-one | |
3.4.22.70 | 0.0896 | - |
- |
Staphylococcus aureus | 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one | |
3.4.22.70 | 0.0902 | - |
- |
Staphylococcus aureus | 3-(dimethylamino)-1-(3-nitrophenyl)propan-1-one | |
3.4.22.70 | 0.0904 | - |
- |
Staphylococcus aureus | 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one | |
3.4.22.70 | 0.0906 | - |
- |
Staphylococcus aureus | 1-(4-chlorophenyl)-3-morpholin-4-ylpropan-1-one | |
3.4.22.70 | 0.0907 | - |
- |
Staphylococcus aureus | 3-(dimethylamino)-1-(2-thienyl)propan-1-one | |
3.4.22.70 | 0.0907 | - |
- |
Staphylococcus aureus | ethyl 4-[3-(4-bromophenyl)-3-oxopropyl]piperazine-1-carboxylate | |
3.4.22.70 | 0.0913 | - |
- |
Staphylococcus aureus | methyl 4-[3-(dimethylamino)propanoyl]benzenesulfinate |