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Literature summary extracted from

  • Puranik, M.; Weeks, C.L.; Lahaye, D.; Kabil, O.; Taoka, S.; Nielsen, S.B.; Groves, J.T.; Banerjee, R.; Spiro, T.G.
    Dynamics of carbon monoxide binding to cystathionine beta-synthase (2006), J. Biol. Chem., 281, 13433-13438.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.22 CO can bind to the cofactor heme, resulting in enzyme inhibition. CBS exhibits strong anticooperativity in CO binding Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Homo sapiens P35520
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-serine + L-homocysteine
-
 Homo sapiens cystathionine + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.22 heme carbon monoxide or nitric oxide can bind to the cofactor, resulting in enzyme inhibition Homo sapiens