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Literature summary extracted from

  • Oshiro, J.; Rangaswamy, S.; Chen, X.; Han, G.S.; Quinn, J.E.; Carman, G.M.
    Regulation of the DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol and growth phase. Inhibition of DGPP phosphatase activity by CDP-diacylglyceron and activation of phosphatidylserine synthase activity by DGPP (2000), J. Biol. Chem., 275, 40887-40896.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.1.75 additional information inositol induces the enzyme in both exponential and stationary phase cells Saccharomyces cerevisiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.75 expression from a plasmid vector bearing the PDPP1-lacZ reporter gene, expression analysis in presence or absence of inositol Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.75 CDP
-
 Saccharomyces cerevisiae
3.6.1.75 CDP-diacylglycerol mixed inhibition mechanism Saccharomyces cerevisiae
3.6.1.75 additional information no or poor inhibition by phospholipids, overview Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.75 34000
-
 x * 34000, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.75 additional information Saccharomyces cerevisiae DGPP phosphatase plays a role in the regulation of phospholipid metabolism by inositol, as well as regulating the cellular levels of phosphatidylinositol, regulation of DGPP phosphatase by inositol and growth phase, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.75 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.75 additional information DGPP phosphatase plays a role in the regulation of phospholipid metabolism by inositol, as well as regulating the cellular levels of phosphatidylinositol, regulation of DGPP phosphatase by inositol and growth phase, overview Saccharomyces cerevisiae ?
-
 ?
3.6.1.75 additional information DGPP stimulates the activity of pure phosphatidylserine synthase by a mechanism that increases the affinity of the enzyme for its substrate CDP-diacylglycerol Saccharomyces cerevisiae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.75 ? x * 34000, SDS-PAGE Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
3.6.1.75 DGPP phosphatase
-
 Saccharomyces cerevisiae
3.6.1.75 diacylglycerol pyrophosphate phosphatase
-
 Saccharomyces cerevisiae
3.6.1.75 DPP1-encoded diacylglycerol pyrophosphate phosphatase
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.75 30
-
 assay at Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.75 5
-
 assay at Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.75 additional information
-
 additional information value for CDP-diacylglacerol is 5 mol% Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.6.1.75 2.6
-
-
 Saccharomyces cerevisiae CDP