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Literature summary extracted from

  • Nitta, Y.; Kikuzaki, H.; Ueno, H.
    Food components inhibiting recombinant human histidine decarboxylase activity (2007), J. Agric. Food Chem., 55, 299-304.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 4-coumaric acid slight inhibition Homo sapiens
4.1.1.22 caffeic acid slight inhibition Homo sapiens
4.1.1.22 curcumin slight inhibition Homo sapiens
4.1.1.22 epicatechin
-
Homo sapiens
4.1.1.22 epicatechin gallate competitive versus L-histidine Homo sapiens
4.1.1.22 epigallocatechin
-
Homo sapiens
4.1.1.22 epigallocatechin gallate time-dependent inhibition, only under aerobic conditions Homo sapiens
4.1.1.22 gallic acid slight inhibition Homo sapiens
4.1.1.22 kaempferol slight inhibition Homo sapiens
4.1.1.22 methylgallate slight inhibition Homo sapiens
4.1.1.22 additional information poor inhibition by procatechiuc acid, ferulic acid, chlorogenic acid, and ellagic acid, no inhibition by luteorin, apigenin and rutin Homo sapiens
4.1.1.22 myricetin
-
Homo sapiens
4.1.1.22 phlorizin slight inhibition Homo sapiens
4.1.1.22 quercetin slight inhibition Homo sapiens
4.1.1.22 rosmarinic acid
-
Homo sapiens
4.1.1.22 Sinapic acid slight inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Homo sapiens histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator histamine + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.22 0.0002
-
purified recombinant enzyme from Saccharomyces cerevisiae Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator Homo sapiens histamine + CO2
-
?
4.1.1.22 L-histidine substrate-specific Homo sapiens histamine + CO2
-
?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.22 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 6.8
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.22 0.01
-
epicatechin gallate pH 6.8, 37°C, recombinant enzyme, versus L-histidine Homo sapiens