EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.22 | 4-coumaric acid | slight inhibition | Homo sapiens | |
4.1.1.22 | caffeic acid | slight inhibition | Homo sapiens | |
4.1.1.22 | curcumin | slight inhibition | Homo sapiens | |
4.1.1.22 | epicatechin | - |
Homo sapiens | |
4.1.1.22 | epicatechin gallate | competitive versus L-histidine | Homo sapiens | |
4.1.1.22 | epigallocatechin | - |
Homo sapiens | |
4.1.1.22 | epigallocatechin gallate | time-dependent inhibition, only under aerobic conditions | Homo sapiens | |
4.1.1.22 | gallic acid | slight inhibition | Homo sapiens | |
4.1.1.22 | kaempferol | slight inhibition | Homo sapiens | |
4.1.1.22 | methylgallate | slight inhibition | Homo sapiens | |
4.1.1.22 | additional information | poor inhibition by procatechiuc acid, ferulic acid, chlorogenic acid, and ellagic acid, no inhibition by luteorin, apigenin and rutin | Homo sapiens | |
4.1.1.22 | myricetin | - |
Homo sapiens | |
4.1.1.22 | phlorizin | slight inhibition | Homo sapiens | |
4.1.1.22 | quercetin | slight inhibition | Homo sapiens | |
4.1.1.22 | rosmarinic acid | - |
Homo sapiens | |
4.1.1.22 | Sinapic acid | slight inhibition | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.22 | L-histidine | Homo sapiens | histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator | histamine + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.22 | Homo sapiens | - |
- |
- |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.1.1.22 | 0.0002 | - |
purified recombinant enzyme from Saccharomyces cerevisiae | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.22 | L-histidine | histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator | Homo sapiens | histamine + CO2 | - |
? | |
4.1.1.22 | L-histidine | substrate-specific | Homo sapiens | histamine + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.22 | HDC | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.1.1.22 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.22 | 6.8 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.22 | pyridoxal 5'-phosphate | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.22 | 0.01 | - |
epicatechin gallate | pH 6.8, 37°C, recombinant enzyme, versus L-histidine | Homo sapiens |