Literature summary extracted from

  • Lall, M.M.; Ferrell, J.; Nagar, S.; Fleisher, L.N.; McGahan, M.C.
    Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase (2008), Invest. Ophthalmol. Vis. Sci., 49, 310-319.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.3 oxalomalic acid inhibition of aconitase activity, leading to inhibition of L-glutamate production, L-cystine uptake, and decrease in glutathione concentration in lens epithelial cells and retinal pigment epithelial cells Canis lupus familiaris

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.3 Iron iron-induced increase in L-glutamate availability increases via the aconitase pathway L-cystine uptake, with subsequent increases in glutathione levels Canis lupus familiaris

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.3 Canis lupus familiaris
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.3 retinal pigment epithelium
-
Canis lupus familiaris
-
4.2.1.3 eye
-
Canis lupus familiaris
-
4.2.1.3 lens epithelium
-
Canis lupus familiaris
-