Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Krisanaprakornkit, S.; Chotjumlong, P.; Kongtawelert, P.; Reutrakul, V.
    Involvement of phospholipase D in regulating expression of anti-microbial peptide human beta-defensin-2 (2008), Int. Immunol., 20, 21-29.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 Fusobacterium nucleatum cell wall extract stimulation Homo sapiens
3.1.4.4 phorbol 12-myristate 13-acetate stimulation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol inhibition of enzyme, leading to block of beta-defensin-2 up-regulation by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate Homo sapiens
3.1.4.4 ethanol inhibition of enzyme, leading to block of beta-defensin-2 up-regulation by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 additional information Homo sapiens up-regulation of beta-defensin-2 by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate is mediated by phospholipase D ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 HGEC cell human gingival epithelial cell. Constitutive expression of PLD1alpha and PLD1beta splice variants and PLD1 protein, whereas PLD2 is expressed at much lower levels than PLD1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information up-regulation of beta-defensin-2 by cell wall extract of Fusobacterium nucleatum or phorbol 12-myristate 13-acetate is mediated by phospholipase D Homo sapiens ?
-
 ?