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Literature summary extracted from

  • Rutkute, K.; Karakashian, A.A.; Giltiay, N.V.; Dobierzewska, A.; Nikolova-Karakashian, M.N.
    Aging in rat causes hepatic hyperresponsiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2 (2007), Hepatology, 46, 1166-1176.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 additional information aging causes increased basal NSMase-2 activity in hepatocytes, which in turn leads to IRAK-1 stabilization, JNK potentiation, and ultimately IL-1beta hyperresponsiveness Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 overexpression of NSMase-2 in hepatocytes Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information overexpression of NSMase-2 in hepatocytes from young rats leads both to a reduction in IRAK-1 degradation and potentiation of JNK phosphorylation, mimicking that seen in hepatocytes from old animals, overview, inhibition of NSMase activity in hepatocytes from aged rats using siRNA leads to reversion to the young phenotype of IL-1beta response, overview Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 scyphostatin inhibition of NSMase activity in hepatocytes from aged rats using leads to reversion to the young phenotype of IL-1beta response Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 plasma membrane NSMase-2 Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Rattus norvegicus aging in rats causes hepatic hyperresponsiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2, NSMase-2 is both required and sufficient for the onset of IL-1beta hyperresponsiveness during aging, overview ?
-
 ?
3.1.4.12 sphingomyelin + H2O Rattus norvegicus
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Rattus norvegicus
-
 male Fisher 344 rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 hepatocyte
-
 Rattus norvegicus
-
3.1.4.12 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)sphingosyl phosphocholine + H2O
-
 Rattus norvegicus 6-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino-N-hexanoylsphingosine + choline phosphate
-
 ?
3.1.4.12 additional information aging in rats causes hepatic hyperresponsiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2, NSMase-2 is both required and sufficient for the onset of IL-1beta hyperresponsiveness during aging, overview Rattus norvegicus ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Rattus norvegicus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral sphingomyelinase-2
-
 Rattus norvegicus
3.1.4.12 NSMase-2
-
 Rattus norvegicus