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Literature summary extracted from

  • Ihara, H.; Ikeda, Y.; Taniguchi, N.
    Reaction mechanism and substrate specificity for nucleotide sugar of mammalian alpha1,6-fucosyltransferase--a large-scale preparation and characterization of recombinant human FUT8 (2006), Glycobiology, 16, 333-342.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.68 large-scale production system for recombinant human FUT8, in which the enzyme is produced in soluble form by baculovirus-infected insect cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.68 ADP
-
 Homo sapiens
2.4.1.68 CDP
-
 Homo sapiens
2.4.1.68 dGDP
-
 Homo sapiens
2.4.1.68 diphosphate
-
 Homo sapiens
2.4.1.68 GDP
-
 Homo sapiens
2.4.1.68 GDP-glucose
-
 Homo sapiens
2.4.1.68 GDP-mannose
-
 Homo sapiens
2.4.1.68 GMP
-
 Homo sapiens
2.4.1.68 GTP
-
 Homo sapiens
2.4.1.68 IDP
-
 Homo sapiens
2.4.1.68 TDP
-
 Homo sapiens
2.4.1.68 UDP
-
 Homo sapiens
2.4.1.68 XDP
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.68 0.0129
-
 Asn-linked agalacto-biantennary sugar chain
-
 Homo sapiens
2.4.1.68 0.0193
-
 GDP-beta-L-fucose
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.68 Golgi apparatus typical type II membrane protein, which is localized in the Golgi apparatus Homo sapiens 5794
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.68 60000
-
 x * 60000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.68 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.68
-
 Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.68 0.417
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.68 GDP-beta-L-fucose + Asn-linked agalacto-biantennary sugar chain
-
 Homo sapiens ?
-
 ?
2.4.1.68 GDP-beta-L-fucose + reducing terminal GlcNAc of the core structure of asparagine-linked oligosaccharide rapid equilibrium random mechanism Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.68 ? x * 60000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.1.68 FUT8
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.68 0.0036
-
 GDP
-
 Homo sapiens
2.4.1.68 0.0077
-
 dGDP
-
 Homo sapiens
2.4.1.68 0.046
-
 GTP
-
 Homo sapiens
2.4.1.68 0.24
-
 GDP-mannose
-
 Homo sapiens
2.4.1.68 0.36
-
 GDP-glucose
-
 Homo sapiens
2.4.1.68 1.3
-
 XDP
-
 Homo sapiens
2.4.1.68 2.3
-
 GMP
-
 Homo sapiens
2.4.1.68 2.4
-
 IDP
-
 Homo sapiens
2.4.1.68 3.1
-
 CDP
-
 Homo sapiens
2.4.1.68 3.9
-
 ADP
-
 Homo sapiens
2.4.1.68 4.1
-
 UDP
-
 Homo sapiens
2.4.1.68 4.3
-
 diphosphate
-
 Homo sapiens
2.4.1.68 5.3
-
 TDP
-
 Homo sapiens