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Literature summary extracted from

  • Tulin, A.; Naumova, N.M.; Menon, A.K.; Spradling, A.C.
    Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing (2006), Genetics, 172, 363-371.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.143 fusion to enhanced green fluorescent protein and expression in Drosophila melanogaster Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.143 additional information decrease or loss of enzyme expression by partial gene deletion or RNA results in mislocalization and hypermodification of silencing protein SIR2 Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.143 additional information Drosophila melanogaster poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase promote chromatin silencing at least in part by regulating the localization and function of silencing protein SIR2 and possible other nuclear proteins ?
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Organism

EC Number Organism UniProt Comment Textmining
3.2.1.143 Drosophila melanogaster
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.143 additional information poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase promote chromatin silencing at least in part by regulating the localization and function of silencing protein SIR2 and possible other nuclear proteins Drosophila melanogaster ?
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 ?