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Literature summary extracted from
- Sphingomyelinase and ceramidase in the intestinal tract (2007), Eur. J. Lipid Sci. Technol., 109, 987-993.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | additional information | feeding psyllium, a water-soluble fiber, increases Alk-SMase and decreases N-CDase activity, and thus might enhance ceramide levels in the intestinal mucosa | Mus musculus |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.5.1.23 | resistant to trypsin digestion | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | CHAPS | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Homo sapiens |  |
| 3.1.4.12 | CHAPS | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Mus musculus | |
| 3.1.4.12 | CHAPS | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Rattus norvegicus | |
| 3.1.4.12 | additional information | Alk-SMase is resistant to trypsin digestion | Homo sapiens | |
| 3.1.4.12 | additional information | Alk-SMase is resistant to trypsin digestion | Mus musculus | |
| 3.1.4.12 | additional information | Alk-SMase is resistant to trypsin digestion | Rattus norvegicus | |
| 3.1.4.12 | Triton X-100 | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Homo sapiens | |
| 3.1.4.12 | Triton X-100 | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Mus musculus | |
| 3.1.4.12 | Triton X-100 | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Rattus norvegicus | |
| 3.1.4.12 | Zn2+ | Alk-SMase | Homo sapiens | |
| 3.1.4.12 | Zn2+ | Alk-SMase | Mus musculus | |
| 3.1.4.12 | Zn2+ | Alk-SMase | Rattus norvegicus | |
| 3.5.1.23 | Triton X-100 | - |
Homo sapiens | |
| 3.5.1.23 | Zn2+ | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.12 | plasma membrane | - |
Mus musculus | 5886 | - |
| 3.1.4.12 | plasma membrane | - |
Homo sapiens | 5886 | - |
| 3.1.4.12 | plasma membrane | - |
Rattus norvegicus | 5886 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.12 | additional information | Mus musculus | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | ? | - |
? | |
| 3.1.4.12 | additional information | Homo sapiens | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | ? | - |
? | |
| 3.1.4.12 | additional information | Rattus norvegicus | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | ? | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | Mus musculus | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | Rattus norvegicus | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | Homo sapiens | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview, dietary SM inhibits colonic carcinogenesis by a mechanism related to SM digestion in the gut, overview | N-acylsphingosine + choline phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | Homo sapiens | - |
- |
- |
| 3.1.4.12 | Mus musculus | - |
- |
- |
| 3.1.4.12 | Rattus norvegicus | - |
- |
- |
| 3.5.1.23 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.5.1.23 | glycoprotein | - |
Homo sapiens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.1.23 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | colon | high activity | Mus musculus | - |
| 3.1.4.12 | colon | high activity | Homo sapiens | - |
| 3.1.4.12 | colon | high activity | Rattus norvegicus | - |
| 3.1.4.12 | colonic cancer cell | - |
Mus musculus | - |
| 3.1.4.12 | colonic cancer cell | - |
Homo sapiens | - |
| 3.1.4.12 | colonic cancer cell | - |
Rattus norvegicus | - |
| 3.1.4.12 | gastrointestinal tract | - |
Mus musculus | - |
| 3.1.4.12 | gastrointestinal tract | - |
Homo sapiens | - |
| 3.1.4.12 | gastrointestinal tract | - |
Rattus norvegicus | - |
| 3.1.4.12 | gut | - |
Mus musculus | - |
| 3.1.4.12 | gut | - |
Homo sapiens | - |
| 3.1.4.12 | gut | - |
Rattus norvegicus | - |
| 3.1.4.12 | jejunum | low activity | Mus musculus | - |
| 3.1.4.12 | jejunum | low activity | Homo sapiens | - |
| 3.1.4.12 | jejunum | low activity | Rattus norvegicus | - |
| 3.1.4.12 | liver | - |
Mus musculus | - |
| 3.1.4.12 | liver | - |
Homo sapiens | - |
| 3.1.4.12 | liver | - |
Rattus norvegicus | - |
| 3.1.4.12 | additional information | Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age | Mus musculus | - |
| 3.1.4.12 | additional information | Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age | Homo sapiens | - |
| 3.1.4.12 | additional information | Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age | Rattus norvegicus | - |
| 3.5.1.23 | ileostomal fluid | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.12 | additional information | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | Mus musculus | ? | - |
? | |
| 3.1.4.12 | additional information | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | Homo sapiens | ? | - |
? | |
| 3.1.4.12 | additional information | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | Rattus norvegicus | ? | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | - |
Mus musculus | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview | Mus musculus | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview | Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview, dietary SM inhibits colonic carcinogenesis by a mechanism related to SM digestion in the gut, overview | Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.12 | acid SMase | - |
Mus musculus |
| 3.1.4.12 | acid SMase | - |
Homo sapiens |
| 3.1.4.12 | acid SMase | - |
Rattus norvegicus |
| 3.1.4.12 | alk-SMase | - |
Mus musculus |
| 3.1.4.12 | alk-SMase | - |
Homo sapiens |
| 3.1.4.12 | alk-SMase | - |
Rattus norvegicus |
| 3.1.4.12 | neutral SMase | - |
Mus musculus |
| 3.1.4.12 | neutral SMase | - |
Homo sapiens |
| 3.1.4.12 | neutral SMase | - |
Rattus norvegicus |
| 3.1.4.12 | SMase | - |
Mus musculus |
| 3.1.4.12 | SMase | - |
Homo sapiens |
| 3.1.4.12 | SMase | - |
Rattus norvegicus |
| 3.5.1.23 | N-CDase | - |
Homo sapiens |
| 3.5.1.23 | neutral ceramidase | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | 9 | - |
- |
Mus musculus |
| 3.1.4.12 | 9 | - |
- |
Homo sapiens |
| 3.1.4.12 | 9 | - |
- |
Rattus norvegicus |
| 3.5.1.23 | 6 | 8 | - |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | 6 | 10.5 | - |
Mus musculus |
| 3.1.4.12 | 6 | 10.5 | - |
Homo sapiens |
| 3.1.4.12 | 6 | 10.5 | - |
Rattus norvegicus |
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