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Literature summary extracted from

  • Erixon, K.M.; Dabalos, C.L.; Leeper, F.J.
    Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics (2007), Chem. Commun. (Camb. ), 2007, 960-962.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.1 2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethyl trihydrogen diphosphate a thiamine diphosphate analogue, almost irreversible inhibition Zymomonas mobilis
4.1.1.1 2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl]ethyl trihydrogen diphosphate a methyl triazole analogue of thiamine diphosphate, almost irreversible inhibition Zymomonas mobilis
4.1.1.1 3-deazathiamine diphosphate 12-step synthesis of the isoelectronic thiophene analogue of thiamine diphosphate, overview Zymomonas mobilis
4.1.1.1 [(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)sulfonyl]phosphoramidic acid a phosphoramidic acid thiamine diphosphate analogue Zymomonas mobilis
4.1.1.1 [[(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)(hydroxy)phosphoryl](difluoro)methyl]phosphonic acid a difluoromethylenediphosphonate ester thiamine diphosphate analogue Zymomonas mobilis
4.1.1.1 [[(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)(hydroxy)phosphoryl]methyl]phosphonic acid a methylenediphosphonate ester thiamine diphosphate analogue Zymomonas mobilis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.1 Mg2+
-
 Zymomonas mobilis

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.1 Zymomonas mobilis
-
-
-

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.1 thiamine diphosphate dependent on Zymomonas mobilis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.1 0.000000014
-
 3-deazathiamine diphosphate below Zymomonas mobilis
4.1.1.1 0.00000002
-
 2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl]ethyl trihydrogen diphosphate
-
 Zymomonas mobilis
4.1.1.1 0.00000003
-
 2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethyl trihydrogen diphosphate
-
 Zymomonas mobilis
4.1.1.1 0.00000095
-
 [[(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)(hydroxy)phosphoryl](difluoro)methyl]phosphonic acid
-
 Zymomonas mobilis
4.1.1.1 0.0000012
-
 [[(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)(hydroxy)phosphoryl]methyl]phosphonic acid
-
 Zymomonas mobilis
4.1.1.1 0.00014
-
 [(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)sulfonyl]phosphoramidic acid
-
 Zymomonas mobilis