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Literature summary extracted from

  • Takada, K.; Hamada, T.; Hirota, H.; Nakao, Y.; Matsunaga, S.; van Soest, R.W.; Fusetani, N.
    Asteropine A, a sialidase-inhibiting conotoxin-like peptide from the marine sponge Asteropus simplex (2006), Chem. Biol., 13, 569-574.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.18 asteropine A a conotoxin-like peptide from the marine sponge Asteropus simplex, competitive inhibition Clostridium perfringens
3.2.1.18 asteropine A a conotoxin-like peptide from the marine sponge Asteropus simplex, competitive inhibition Salmonella enterica subsp. enterica serovar Typhimurium
3.2.1.18 asteropine A a conotoxin-like peptide from the marine sponge Asteropus simplex, competitive inhibition Vibrio cholerae serotype O1
3.2.1.18 additional information no inhibition by asteropine A influenza A virus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 Clostridium perfringens
-
-
-
3.2.1.18 influenza A virus
-
-
-
3.2.1.18 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
3.2.1.18 Vibrio cholerae serotype O1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium 4-methylumbelliferone + N-acetyl-alpha-D-neuraminic acid
-
 ?
3.2.1.18 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
 Clostridium perfringens 4-methylumbelliferone + N-acetyl-alpha-D-neuraminic acid
-
 ?
3.2.1.18 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
 Vibrio cholerae serotype O1 4-methylumbelliferone + N-acetyl-alpha-D-neuraminic acid
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.18 0.0000367
-
 asteropine A
-
 Clostridium perfringens
3.2.1.18 0.00034
-
 asteropine A
-
 Vibrio cholerae serotype O1
3.2.1.18 0.00035
-
 asteropine A
-
 Salmonella enterica subsp. enterica serovar Typhimurium