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Literature summary extracted from

  • Katona, A.; Tosa, M.I.; Paizs, C.; Retey, J.
    Inhibition of histidine ammonia lyase by heteroaryl-alanines and acrylates (2006), Chem. Biodivers., 3, 502-508.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.1.3 into the pT7-7 vector for expression in Escherichia coli BL21DE3 cells Pseudomonas putida

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.3 (2E)-3-(1-benzofuran-2-yl)prop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-(1-benzofuran-3-yl)prop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-(1-benzothiophen-2-yl)prop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-(1-benzothiophen-3-yl)prop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-(1-methyl-1H-indol-3-yl)prop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-(1H-indol-3-yl)prop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-(3-methylfuran-2-yl)prop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-furan-2-ylprop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 (2E)-3-thiophen-2-ylprop-2-enoic acid
-
Pseudomonas putida
4.3.1.3 1-Methyltryptophan
-
Pseudomonas putida
4.3.1.3 3-(1-benzofuran-2-yl)alanine
-
Pseudomonas putida
4.3.1.3 3-(1-benzofuran-3-yl)alanine
-
Pseudomonas putida
4.3.1.3 3-(1-benzothiophen-2-yl)alanine
-
Pseudomonas putida
4.3.1.3 3-(1-benzothiophen-3-yl)alanine
-
Pseudomonas putida
4.3.1.3 3-(3-methylthiophen-2-yl)alanine
-
Pseudomonas putida
4.3.1.3 3-furan-2-ylalanine
-
Pseudomonas putida
4.3.1.3 3-thiophen-2-ylalanine
-
Pseudomonas putida
4.3.1.3 norhistidine
-
Pseudomonas putida
4.3.1.3 tryptophan
-
Pseudomonas putida

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.3 L-histidine Pseudomonas putida
-
urocanate + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.3 Pseudomonas putida
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.1.3
-
Pseudomonas putida

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.3 L-histidine
-
Pseudomonas putida urocanate + NH3
-
?

Synonyms

EC Number Synonyms Comment Organism
4.3.1.3 HAL
-
Pseudomonas putida
4.3.1.3 histidine ammonia-lyase
-
Pseudomonas putida

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.3.1.3 25
-
activity assay Pseudomonas putida

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.3.1.3 9.3
-
activity assay Pseudomonas putida

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.3.1.3 0.015
-
(2E)-3-(1H-indol-3-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.018
-
(2E)-3-(3-methylfuran-2-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.023
-
(2E)-3-(1-benzofuran-3-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.025
-
3-(1-benzofuran-2-yl)alanine competitive inhibition Pseudomonas putida
4.3.1.3 0.026
-
(2E)-3-(1-methyl-1H-indol-3-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.031
-
1-Methyltryptophan mixed inhibition Pseudomonas putida
4.3.1.3 0.033
-
(2E)-3-furan-2-ylprop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.039
-
(2E)-3-(1-benzothiophen-2-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.04
-
(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.041
-
(2E)-3-thiophen-2-ylprop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.05
-
tryptophan mixed inhibition Pseudomonas putida
4.3.1.3 0.053
-
(2E)-3-(1-benzothiophen-3-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.056
-
(2E)-3-(1-benzofuran-2-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
4.3.1.3 0.067
-
3-(1-benzofuran-3-yl)alanine competitive inhibition Pseudomonas putida
4.3.1.3 0.082
-
3-(1-benzothiophen-3-yl)alanine competitive inhibition Pseudomonas putida
4.3.1.3 0.083
-
3-(1-benzothiophen-2-yl)alanine competitive inhibition Pseudomonas putida
4.3.1.3 0.098
-
3-(3-methylthiophen-2-yl)alanine competitive inhibition Pseudomonas putida
4.3.1.3 0.101
-
3-thiophen-2-ylalanine competitive inhibition Pseudomonas putida
4.3.1.3 0.139
-
3-furan-2-ylalanine competitive inhibition Pseudomonas putida
4.3.1.3 1.72
-
norhistidine mixed inhibition Pseudomonas putida