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Literature summary extracted from
- Human xylosyltransferases in health and disease (2007), Cell. Mol. Life Sci., 64, 1498-1517.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 2.4.2.26 | medicine | serum xylosyltransferase activity is a biochemical marker for the assessment of disease activity in systemic sclerosis and for the diagnosis of fibrotic remodeling processes. Sequence variations in the XT-I and XT-II coding genes are identified as risk factors for diabetic nephropathy, osteoarthritis or pseudoxanthoma elasticum. Important role of the xylosyltransferases as disease modifiers in pathologies which are characterized by an altered proteoglycan metabolism | Homo sapiens |
| 2.4.2.26 | medicine | serum xylosyltransferase activity is a biochemical marker for the assessment of disease activity in systemic sclerosis and for the diagnosis of fibrotic remodeling processes, sequence variations in the XT-I coding gene are identified as risk factors for diabetic nephropathy, osteoarthritis or pseudoxanthoma elasticum | Homo sapiens |
| 2.4.2.26 | medicine | serum xylosyltransferase activity is a biochemical marker for the assessment of disease activity in systemic sclerosis and for the diagnosis of fibrotic remodeling processes, sequence variations in the XT-II coding gene are identified as risk factors for diabetic nephropathy, osteoarthritis or pseudoxanthoma elasticum | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.4.2.26 | - |
Homo sapiens |
| 2.4.2.26 | expressed in CHO cells, high five insect cells, HEK293 cells, and SaOS-2 cells, and in Pichia pastoris | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.26 | Cu2+ | enzyme activity is abolished by Cu2+ | Homo sapiens |  |
| 2.4.2.26 | Ni2+ | enzyme activity is abolished by Ni2+ | Homo sapiens | |
| 2.4.2.26 | Zn2+ | enzyme activity is abolished by Zn2+ | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.4.2.26 | Golgi apparatus | - |
Homo sapiens | 5794 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.26 | Ca2+ | activates | Homo sapiens | |
| 2.4.2.26 | Mg2+ | - |
Homo sapiens | |
| 2.4.2.26 | Mn2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.26 | 97000 | - |
x * 97000, calculated from sequence | Homo sapiens |
| 2.4.2.26 | 120000 | - |
- |
Homo sapiens |
| 2.4.2.26 | 120000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.26 | UDP-D-xylose + proteoglycan core protein | Homo sapiens | the xylosyltransferases I and II catalyze the transfer of xylose from UDP-xylose to selected serine residues in the proteoglycan core protein, which is the initial and rate limiting step in glycosaminoglycan biosynthesis | UDP + proteoglycan core protein with xyloserine | - |
? | |
| 2.4.2.26 | UDP-D-xylose + proteoglycan core protein | Homo sapiens | the xylosyltransferases I and II catalyze the transfer of xylose from UDP-xylose to selected serine residues in the proteoglycan core protein, which is the initial and rate limiting step in glycosaminoglycan biosynthesis | UDP + proteoglycan core protein with xylosylserine | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.2.26 | Homo sapiens | Q86Y38 | - |
- |
| 2.4.2.26 | Homo sapiens | Q9H1B5 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.4.2.26 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.4.2.26 | HeLa cell | expresson of xylosyltransferase 2, no expression of xylosyltransferase 1 | Homo sapiens | - |
| 2.4.2.26 | HeLa cell | XT-II is exclusively expressed in liver tissues, in the HeLa cervical carcinoma cell line, and in K-562 erythroleukemia cells | Homo sapiens | - |
| 2.4.2.26 | JAR cell | - |
Homo sapiens | - |
| 2.4.2.26 | K-562 cell | expresson of xylosyltransferase 2, no expression of xylosyltransferase 1 | Homo sapiens | - |
| 2.4.2.26 | liver | expresson of xylosyltransferase 2, no expression of xylosyltransferase 1 | Homo sapiens | - |
| 2.4.2.26 | liver | XT-II is exclusively expressed in liver tissues, in the HeLa cervical carcinoma cell line, and in K-562 erythroleukemia cells | Homo sapiens | - |
| 2.4.2.26 | mesenchymal stem cell | mesenchymal stem cell. Xylosyltransferase 1 is the predominant xylosyltransferase in the early phase of chondrogenic stem cell differentiation and xylosyltransferase 2 is upregulated 7 days after induction | Homo sapiens | - |
| 2.4.2.26 | mesenchyme | mesenchymal stem cell | Homo sapiens | - |
| 2.4.2.26 | mesenchyme | mesenchymal stem cell. Xylosyltransferase 1 is the predominant xylosyltransferase in the early phase of chondrogenic stem cell differentiation and xylosyltransferase 2 is upregulated 7 days after induction | Homo sapiens | - |
| 2.4.2.26 | serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.26 | UDP-D-xylose + biglycan | - |
Homo sapiens | UDP + D-xylosyl-biglycan | - |
? | |
| 2.4.2.26 | UDP-D-xylose + biglycan | - |
Homo sapiens | UDP + xylosyl-biglycan | - |
? | |
| 2.4.2.26 | UDP-D-xylose + bikunin | - |
Homo sapiens | UDP + D-xylosyl-bikunin | - |
? | |
| 2.4.2.26 | UDP-D-xylose + biotin-NHQEEEGSGGGQKK(5-fluorescein)-CONH2 | - |
Homo sapiens | UDP + biotin-NHQEEEG-(D-xylosyl)SGGGQKK(5-fluorescein)-CONH2 | - |
? | |
| 2.4.2.26 | UDP-D-xylose + biotin-NHQEEEGSGGGQKK(5-fluorescein)-CONH2 | biotin-NHQEEEGSGGGQKK(5-fluorescein)-CONH2is the best acceptor for isozyme XT-II | Homo sapiens | UDP + biotin-NHQEEEG-(D-xylosyl)SGGGQKK(5-fluorescein)-CONH2 | - |
? | |
| 2.4.2.26 | UDP-D-xylose + fibroblast growth factor 2 peptide | - |
Homo sapiens | ? | - |
? | |
| 2.4.2.26 | UDP-D-xylose + proteoglycan core protein | the xylosyltransferases I and II catalyze the transfer of xylose from UDP-xylose to selected serine residues in the proteoglycan core protein, which is the initial and rate limiting step in glycosaminoglycan biosynthesis | Homo sapiens | UDP + proteoglycan core protein with xyloserine | - |
? | |
| 2.4.2.26 | UDP-D-xylose + proteoglycan core protein | the xylosyltransferases I and II catalyze the transfer of xylose from UDP-xylose to selected serine residues in the proteoglycan core protein, which is the initial and rate limiting step in glycosaminoglycan biosynthesis | Homo sapiens | UDP + proteoglycan core protein with xylosylserine | - |
? | |
| 2.4.2.26 | UDP-D-xylose + silk fibroin | - |
Homo sapiens | UDP + silk fibroin with xylosylserine | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.4.2.26 | ? | x * 97000, calculated from sequence | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.4.2.26 | peptide O-xylosyltransferase 1 | - |
Homo sapiens |
| 2.4.2.26 | UDP-D-xylose:proteoglycan core protein b-d-xylosyltransferase | - |
Homo sapiens |
| 2.4.2.26 | XT-I | - |
Homo sapiens |
| 2.4.2.26 | XT-I | isozyme | Homo sapiens |
| 2.4.2.26 | XT-II | - |
Homo sapiens |
| 2.4.2.26 | XT-II | isozyme | Homo sapiens |
| 2.4.2.26 | xylosyltransferase 1 | - |
Homo sapiens |
| 2.4.2.26 | xylosyltransferase 2 | - |
Homo sapiens |
| 2.4.2.26 | xylosyltransferase I | - |
Homo sapiens |
| 2.4.2.26 | xylosyltransferase I | isozyme | Homo sapiens |
| 2.4.2.26 | xylosyltransferase II | - |
Homo sapiens |
| 2.4.2.26 | xylosyltransferases II | isozyme | Homo sapiens |
| 2.4.2.26 | XylT-I | - |
Homo sapiens |
| 2.4.2.26 | XylT-II | - |
Homo sapiens |
| 2.4.2.26 | XYLT1 | - |
Homo sapiens |
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