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Literature summary extracted from

  • Zimmerman, W.C.; Erikson, R.L.
    Finding Plk3 (2007), Cell Cycle, 6, 1314-1318.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.21 additional information only one polo kinase found, is a master mitotic regulator, involved in the regulation of mitotic entry, the metaphase to anaphase transition, mitotic exit and cytokinesis Drosophila melanogaster
2.7.11.21 additional information only one polo kinase found, is a master mitotic regulator, involved in the regulation of mitotic entry, the metaphase to anaphase transition, mitotic exit and cytokinesis Saccharomyces cerevisiae
2.7.11.21 additional information Plk1 functions during mitosis and cytokinesis Homo sapiens
2.7.11.21 additional information Plk2 is expressed earlier in the cell cycle Homo sapiens
2.7.11.21 additional information Plk3 is expressed earlier in the cell cycle, regulates entry into S phase, attenuates cyclin E expression through a post transcriptional mechanism, it must be a critical regulator of G1 events Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.21
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.21 ONO1910 does not significantly impacting Plk3 activity in vitro; inhibits Plk1 activity without significantly impacting Plk3 activity in vitro Homo sapiens
2.7.11.21 RNAi induces Plk3 depletion, which causes a large fraction of cells to become quiescent, Plk3-depleted cells appear to pass through mitosis normally and complete cell division, but failed to reenter the cell cycle Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.21 centrosome Plk1 expressed during G2 and mitosis Homo sapiens 5813
-
2.7.11.21 kinetochore Plk1 expressed during G2 and mitosis Homo sapiens 776
-
2.7.11.21 additional information Plk1 is expressed during G2 and mitosis at the midbody Homo sapiens
-
-
2.7.11.21 nucleolus Plk3, as long as the nucleolus is intact, and is undetectable during mitosis Homo sapiens 5730
-
2.7.11.21 spindle Plk1 is expressed during G2 and mitosis at the spindle pole and spindle midzone Homo sapiens 5819
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Drosophila melanogaster
-
-
-
2.7.11.21 Homo sapiens P53350
-
-
2.7.11.21 Homo sapiens Q9H4B4
-
-
2.7.11.21 Homo sapiens Q9NYY3
-
-
2.7.11.21 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.21 MCF-10A cell
-
 Homo sapiens
-
2.7.11.21 MCF-10A cell Plk3 accumulates by serum starvation, at a point in the cell cycle commonly referred to as G0 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 ATP + Cdc25A
-
 Homo sapiens ADP + phosphorylated Cdc25A
-
 ?
2.7.11.21 ATP + p53 Plk1 apparently phosphorylates other residues than Plk3 Homo sapiens ADP + phosphorylated p53
-
 ?
2.7.11.21 ATP + p53 Plk3 apparently phosphorylates other residues than Plk1 Homo sapiens ADP + phosphorylated p53
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.21 Plk1
-
 Homo sapiens
2.7.11.21 Plk2
-
 Homo sapiens
2.7.11.21 Plk3
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.21 0.000009
-
-
 Homo sapiens ONO1910
2.7.11.21 0.00026
-
 Plk2 Homo sapiens ONO1910
2.7.11.21 0.01
-
-
 Homo sapiens ONO1910