Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cheng, Y.; Wu, J.; Hertervig, E.; Lindgren, S.; Duan, D.; Nilsson, A.; Duan, R.D.
    Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis (2007), Br. J. Cancer, 97, 1441-1448.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 alkaline sphingomyelinase, cloning and DNA and amino acid sequence determination and analysis from Hep-G2 cancer cells, transient expression of mutant alkaline sphingomyelinase forms in COS-7 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information naturally occuring mutant enzyme forms in the liver are full-length enzymes which contain an additional 73 amino acid sequence at the N-terminus that reduces the enzyme activity, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens Q6UWV6 gene ENPP7; gene ENPP7
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 Hep-G2 cell expression analysis of alkaline sphingomyelinase forms, overview Homo sapiens
-
3.1.4.12 hepatoma cell
-
 Homo sapiens
-
3.1.4.12 intestine
-
 Homo sapiens
-
3.1.4.12 liver wild-type and mutant alkaline sphingomyelinase forms Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.12 0.007
-
 alkaline sphingomyelinase in liver with steatosis Homo sapiens
3.1.4.12 0.047
-
 alkaline sphingomyelinase in liver with sclerosing cholangitis Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information wild-type alkaline sphingomyelinase inhibits colonic tumorigenesis, while enzyme deficiency or aberrant enzyme forms are associated with human liver tumorigenesis, the enzyme activity is increased in cholestatic liver disease excluding primary sclerosing cholangitis, overview Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 alk-SMase
-
 Homo sapiens
3.1.4.12 alkaline sphingomyelinase
-
 Homo sapiens
3.1.4.12 NPP7
-
 Homo sapiens