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Literature summary extracted from

  • Chenna, B.C.; Shinkre, B.A.; King, J.R.; Lucius, A.L.; Narayana, S.V.; Velu, S.E.
    Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus sortase A (2008), Bioorg. Med. Chem. Lett., 18, 380-385.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.70 (1E)-N'-[(1E)-(4-[(E)-[(diaminomethylene)hydrazono]methyl]phenyl)methylene]ethanehydrazonamide
-
 Staphylococcus aureus
3.4.22.70 (2E)-2-(2-furoyl)-3-[(methyl[4-[(5-nitropyridin-2-yl)oxy]phenyl]oxido-l4-sulfanylidene)amino]acrylonitrile
-
 Staphylococcus aureus
3.4.22.70 (2E)-3-(2-furyl)-N-[3-(hydroxymethyl)-4-morpholin-4-ylphenyl]acrylamide
-
 Staphylococcus aureus
3.4.22.70 (2E)-3-[(methyl[4-[(5-nitropyridin-2-yl)oxy]phenyl]oxido-l4-sulfanylidene)amino]-2-(2-thienylcarbonyl)acrylonitrile
-
 Staphylococcus aureus
3.4.22.70 (2E)-4-([4-[(2-hydroxybenzoyl)amino]phenyl]amino)-4-oxobut-2-enoic acid
-
 Staphylococcus aureus
3.4.22.70 (2E)-N-(3-formyl-4-morpholin-4-ylphenyl)-3-(2-furyl)acrylamide
-
 Staphylococcus aureus
3.4.22.70 (2E)-N-(3-formyl-4-morpholin-4-ylphenyl)-3-(2-thienyl)acrylamide
-
 Staphylococcus aureus
3.4.22.70 (2E)-N-[3-(hydroxymethyl)-4-morpholin-4-ylphenyl]-3-(2-thienyl)acrylamide
-
 Staphylococcus aureus
3.4.22.70 1-[4-(2-aminopyrimidin-4-yl)phenyl]-3-(4-chlorophenyl)urea
-
 Staphylococcus aureus
3.4.22.70 2-hydroxy-N-[4-[([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]phenyl]benzamide
-
 Staphylococcus aureus
3.4.22.70 2-morpholin-4-yl-5-[[(2E)-3-(2-thienyl)prop-2-enoyl]amino]benzamide
-
 Staphylococcus aureus
3.4.22.70 3,5-bis[[2-(4-nitrophenyl)-2-oxoethyl]thio]isothiazole-4-carbonitrile
-
 Staphylococcus aureus
3.4.22.70 5-[[(2E)-3-(2-furyl)prop-2-enoyl]amino]-2-morpholin-4-ylbenzoic acid
-
 Staphylococcus aureus
3.4.22.70 methyl 2-morpholin-4-yl-5-[[(2E)-3-(2-thienyl)prop-2-enoyl]amino]benzoate
-
 Staphylococcus aureus
3.4.22.70 methyl 5-[[(2E)-3-(2-furyl)prop-2-enoyl]amino]-2-morpholin-4-ylbenzoate
-
 Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.70 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.70 [4-(4-dimethylaminophenylazo)benzoic acid]-QALPETGEE-[5-[2'-(aminoethyl)amino]-naphthalenesulfonic acid] + H2O
-
 Staphylococcus aureus ?
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.70 0.058
-
-
 Staphylococcus aureus methyl 5-[[(2E)-3-(2-furyl)prop-2-enoyl]amino]-2-morpholin-4-ylbenzoate
3.4.22.70 0.071
-
-
 Staphylococcus aureus methyl 2-morpholin-4-yl-5-[[(2E)-3-(2-thienyl)prop-2-enoyl]amino]benzoate
3.4.22.70 0.073
-
-
 Staphylococcus aureus (2E)-N-[3-(hydroxymethyl)-4-morpholin-4-ylphenyl]-3-(2-thienyl)acrylamide
3.4.22.70 0.077
-
-
 Staphylococcus aureus (2E)-N-(3-formyl-4-morpholin-4-ylphenyl)-3-(2-thienyl)acrylamide
3.4.22.70 0.0973
-
-
 Staphylococcus aureus 3,5-bis[[2-(4-nitrophenyl)-2-oxoethyl]thio]isothiazole-4-carbonitrile
3.4.22.70 0.105
-
-
 Staphylococcus aureus 2-morpholin-4-yl-5-[[(2E)-3-(2-thienyl)prop-2-enoyl]amino]benzamide
3.4.22.70 0.107
-
-
 Staphylococcus aureus (2E)-N-(3-formyl-4-morpholin-4-ylphenyl)-3-(2-furyl)acrylamide
3.4.22.70 0.111
-
-
 Staphylococcus aureus (2E)-3-(2-furyl)-N-[3-(hydroxymethyl)-4-morpholin-4-ylphenyl]acrylamide
3.4.22.70 0.125
-
-
 Staphylococcus aureus (2E)-4-([4-[(2-hydroxybenzoyl)amino]phenyl]amino)-4-oxobut-2-enoic acid
3.4.22.70 0.15
-
-
 Staphylococcus aureus (2E)-2-(2-furoyl)-3-[(methyl[4-[(5-nitropyridin-2-yl)oxy]phenyl]oxido-l4-sulfanylidene)amino]acrylonitrile
3.4.22.70 0.181
-
-
 Staphylococcus aureus 5-[[(2E)-3-(2-furyl)prop-2-enoyl]amino]-2-morpholin-4-ylbenzoic acid
3.4.22.70 0.226
-
-
 Staphylococcus aureus 2-hydroxy-N-[4-[([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]phenyl]benzamide
3.4.22.70 0.275
-
-
 Staphylococcus aureus (1E)-N'-[(1E)-(4-[(E)-[(diaminomethylene)hydrazono]methyl]phenyl)methylene]ethanehydrazonamide
3.4.22.70 0.4
-
-
 Staphylococcus aureus (2E)-3-[(methyl[4-[(5-nitropyridin-2-yl)oxy]phenyl]oxido-l4-sulfanylidene)amino]-2-(2-thienylcarbonyl)acrylonitrile
3.4.22.70 0.4
-
-
 Staphylococcus aureus 1-[4-(2-aminopyrimidin-4-yl)phenyl]-3-(4-chlorophenyl)urea