Any feedback?
Literature summary extracted from
- Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides - solution and crystallographic studies (2007), Bioorg. Med. Chem. Lett., 17, 4201-4207.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | 2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hpalphaCA; isoenzyme hpbetaCA | Helicobacter pylori |  |
| 4.2.1.1 | 2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hpalphaCA, i.e. daranide; isoenzyme hpbetaCA, i.e. daranide | Helicobacter pylori | |
| 4.2.1.1 | 4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA I, i.e. daranide; isoenzyme hCA II, i.e. daranide; isoenzyme hCA III, i.e. daranide; isoenzyme hCA IV, i.e. daranide; isoenzyme hCA IX, i.e. daranide; isoenzyme hCA VA, i.e. daranide; isoenzyme hCA VB, i.e. daranide; isoenzyme hCA VI, i.e. daranide; isoenzyme hCA VII, i.e. daranide; isoenzyme hCA XII, i.e. daranide; isoenzyme hCA XIV, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme gammaCA, i.e. daranide | Methanosarcina thermophila | |
| 4.2.1.1 | 4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme mCA XIII, i.e. daranide | Mus musculus | |
| 4.2.1.1 | 6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hpalphaCA; isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hpalphaCA; isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA III; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hpalphaCA; isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | acetazolamide | isoenzyme hpalphaCA; isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | acetazolamide | isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | acetazolamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | acetazolamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | ethoxzolamide | isoenzyme hpalphaCA; isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | ethoxzolamide | isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | ethoxzolamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | ethoxzolamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | Furosemide | isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | Furosemide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | hydrochlorothiazide | isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | hydrochlorothiazide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hpalphaCA; isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA III; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | topiramate | isoenzyme hpalphaCA; isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | topiramate | isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | topiramate | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | topiramate | isoenzyme mCA XIII | Mus musculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | Helicobacter pylori | O24855 | - |
- |
| 4.2.1.1 | Helicobacter pylori | Q1CVF1 | - |
- |
| 4.2.1.1 | Homo sapiens | O43570 | - |
- |
| 4.2.1.1 | Homo sapiens | P00915 | - |
- |
| 4.2.1.1 | Homo sapiens | P00918 | - |
- |
| 4.2.1.1 | Homo sapiens | P07451 | - |
- |
| 4.2.1.1 | Homo sapiens | P22748 | - |
- |
| 4.2.1.1 | Homo sapiens | P23280 | - |
- |
| 4.2.1.1 | Homo sapiens | P35218 | - |
- |
| 4.2.1.1 | Homo sapiens | P43166 | - |
- |
| 4.2.1.1 | Homo sapiens | Q16790 | - |
- |
| 4.2.1.1 | Homo sapiens | Q9ULX7 | - |
- |
| 4.2.1.1 | Homo sapiens | Q9Y2D0 | - |
- |
| 4.2.1.1 | Methanosarcina thermophila | P40881 | - |
- |
| 4.2.1.1 | Mus musculus | Q9D6N1 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.1 | gammaCA | - |
Methanosarcina thermophila |
| 4.2.1.1 | hCA I | - |
Homo sapiens |
| 4.2.1.1 | HCA II | - |
Homo sapiens |
| 4.2.1.1 | hCA III | - |
Homo sapiens |
| 4.2.1.1 | hCA IV | - |
Homo sapiens |
| 4.2.1.1 | hCA IX | - |
Homo sapiens |
| 4.2.1.1 | hCA VA | - |
Homo sapiens |
| 4.2.1.1 | hCA VB | - |
Homo sapiens |
| 4.2.1.1 | hCA VI | - |
Homo sapiens |
| 4.2.1.1 | hCA VII | - |
Homo sapiens |
| 4.2.1.1 | hCA XII | - |
Homo sapiens |
| 4.2.1.1 | hCA XIV | - |
Homo sapiens |
| 4.2.1.1 | hpalphaCA | - |
Helicobacter pylori |
| 4.2.1.1 | hpbetaCA | - |
Helicobacter pylori |
| 4.2.1.1 | mCA XIII | - |
Mus musculus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 0.0000008 | - |
ethoxzolamide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.0000009 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.0000009 | - |
topiramate | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.0000021 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.0000025 | - |
acetazolamide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.0000028 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.000003 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.000003 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.0000035 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.0000035 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.0000057 | - |
acetazolamide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.000008 | - |
ethoxzolamide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.000009 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.00001 | - |
topiramate | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.00001 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.00001 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.000011 | - |
acetazolamide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.000012 | - |
acetazolamide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.000014 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.000017 | - |
acetazolamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 0.000018 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 0.000019 | - |
ethoxzolamide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.000019 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 0.00002 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 0.000021 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA VB, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.000021 | - |
acetazolamide | isoenzyme hpalphaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.000021 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 0.000022 | - |
ethoxzolamide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.000023 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme mCA XIII, i.e. daranide | Mus musculus | |
| 4.2.1.1 | 0.000024 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000024 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.000025 | - |
acetazolamide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000025 | - |
ethoxzolamide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.000025 | - |
ethoxzolamide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.000026 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA VII, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.000027 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000027 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.00003 | - |
topiramate | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.00003 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.000032 | - |
topiramate | isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.000033 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.000033 | - |
ethoxzolamide | isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.000034 | - |
ethoxzolamide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000034 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.000037 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000038 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA II, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.000038 | - |
topiramate | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.000039 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.00004 | - |
acetazolamide | isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.000041 | - |
acetazolamide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.000042 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.000043 | - |
ethoxzolamide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.000043 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.000044 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.000045 | - |
topiramate | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.000045 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.000047 | - |
topiramate | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 0.000049 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hpalphaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.00005 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.00005 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA IX, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.00005 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.00005 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA XII, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.000052 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000052 | - |
Furosemide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.000054 | - |
acetazolamide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.000058 | - |
topiramate | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000062 | - |
Furosemide | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.000062 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.000063 | - |
acetazolamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 0.000063 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.000063 | - |
acetazolamide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.000063 | - |
topiramate | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.000065 | - |
Furosemide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.000065 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.000073 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.000074 | - |
acetazolamide | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.000075 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.000079 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA VI, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.000093 | - |
ethoxzolamide | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.0001 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.000105 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hpbetaCA, i.e. daranide | Helicobacter pylori | |
| 4.2.1.1 | 0.00012 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 0.000128 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.00014 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 0.000172 | - |
topiramate | isoenzyme hpalphaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.000176 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.00019 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme gammaCA, i.e. daranide | Methanosarcina thermophila | |
| 4.2.1.1 | 0.000193 | - |
ethoxzolamide | isoenzyme hpalphaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.0002 | - |
ethoxzolamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 0.00021 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.00021 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hpalphaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.000225 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hpalphaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.000245 | - |
Furosemide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.00025 | - |
acetazolamide | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.00025 | - |
ethoxzolamide | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.00025 | - |
topiramate | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.000261 | - |
Furosemide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.00029 | - |
hydrochlorothiazide | isoenzyme hCA II | Homo sapiens | |
| 4.2.1.1 | 0.000322 | - |
Furosemide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.000328 | - |
hydrochlorothiazide | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.000345 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA XIV, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.000355 | - |
hydrochlorothiazide | isoenzyme hCA XII | Homo sapiens | |
| 4.2.1.1 | 0.000367 | - |
hydrochlorothiazide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000378 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hpalphaCA, i.e. daranide | Helicobacter pylori | |
| 4.2.1.1 | 0.00038 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.00041 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 0.000412 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hpalphaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.00042 | - |
Furosemide | isoenzyme hCA IX | Homo sapiens | |
| 4.2.1.1 | 0.000427 | - |
hydrochlorothiazide | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.00046 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 0.000499 | - |
Furosemide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.000513 | - |
Furosemide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.00055 | - |
Furosemide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 0.000564 | - |
Furosemide | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.00057 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.000603 | - |
hydrochlorothiazide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.000608 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.00063 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA VA, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.00064 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.00068 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.00083 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 0.000955 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.000973 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hpbetaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.00102 | - |
topiramate | isoenzyme gammaCA | Methanosarcina thermophila | |
| 4.2.1.1 | 0.0012 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA I, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.00146 | - |
topiramate | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.003655 | - |
hydrochlorothiazide | isoenzyme hCA VI | Homo sapiens | |
| 4.2.1.1 | 0.003885 | - |
hydrochlorothiazide | isoenzyme mCA XIII | Mus musculus | |
| 4.2.1.1 | 0.004105 | - |
hydrochlorothiazide | isoenzyme hCA XIV | Homo sapiens | |
| 4.2.1.1 | 0.00415 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.004225 | - |
hydrochlorothiazide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.00436 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hpalphaCA | Helicobacter pylori | |
| 4.2.1.1 | 0.0048 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.0049 | - |
topiramate | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.005 | - |
ethoxzolamide | isoenzyme hCA III | Homo sapiens | |
| 4.2.1.1 | 0.00501 | - |
hydrochlorothiazide | isoenzyme hCA VII | Homo sapiens | |
| 4.2.1.1 | 0.0058 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.0062 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.0062 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.0063 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA III, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.0065 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA VB | Homo sapiens | |
| 4.2.1.1 | 0.0068 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA III | Homo sapiens | |
| 4.2.1.1 | 0.0072 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA III | Homo sapiens | |
| 4.2.1.1 | 0.0084 | - |
6-chloro-4-amino-benzene-1,3-disulfonamide | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.0085 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA IV | Homo sapiens | |
| 4.2.1.1 | 0.0094 | - |
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide | isoenzyme hCA VA | Homo sapiens | |
| 4.2.1.1 | 0.015 | - |
4,5-dichloro-benzene-1,3-disulfonamide | isoenzyme hCA IV, i.e. daranide | Homo sapiens | |
| 4.2.1.1 | 0.05 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA I | Homo sapiens | |
| 4.2.1.1 | 0.1 | - |
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide | isoenzyme hCA III | Homo sapiens | |
| 4.2.1.1 | 0.3 | - |
acetazolamide | isoenzyme hCA III | Homo sapiens | |
| 4.2.1.1 | 8 | - |
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | isoenzyme hCA III | Homo sapiens | |
| 4.2.1.1 | 45 | - |
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide | isoenzyme hCA I | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
