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Literature summary extracted from

  • Suzuki, H.; Sawanishi, H.; Nomura, M.; Shimada, T.; Miyamoto, K.
    Effects of 1-benzylxanthines on cyclic AMP phosphodiesterase 4 isoenzyme (2006), Biol. Pharm. Bull., 29, 131-134.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 1-(2-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-(2-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-(3-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-(3-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-(3-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-(4-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-(4-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-(4-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 1-benzyl-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.17 IBMX
-
 Cavia porcellus
3.1.4.53 1-(2,4-dichlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(2-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(2-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(3-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(3-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(3-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(4-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(4-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-(4-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 1-benzyl-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
-
 Cavia porcellus
3.1.4.53 rolipram
-
 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Cavia porcellus
-
 isoform PDE1
-
3.1.4.53 Cavia porcellus
-
 isoform PDE4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 brain
-
 Cavia porcellus
-
3.1.4.53 brain
-
 Cavia porcellus
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.17 0.0007
-
-
 Cavia porcellus 1-(4-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.0014
-
-
 Cavia porcellus 1-(4-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.0015
-
-
 Cavia porcellus 1-(4-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.0023
-
-
 Cavia porcellus 1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.0043
-
-
 Cavia porcellus IBMX
3.1.4.17 0.0095
-
-
 Cavia porcellus 1-(3-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.0097
-
-
 Cavia porcellus 1-(3-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.016
-
-
 Cavia porcellus 1-(3-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.028
-
-
 Cavia porcellus 1-benzyl-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.052
-
-
 Cavia porcellus 1-(2-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.17 0.053
-
-
 Cavia porcellus 1-(2-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0001
-
-
 Cavia porcellus rolipram
3.1.4.53 0.0001
-
-
 Cavia porcellus 1-(2,4-dichlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0002
-
-
 Cavia porcellus 1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0006
-
-
 Cavia porcellus 1-(4-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0009
-
-
 Cavia porcellus 1-(4-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0009
-
-
 Cavia porcellus 1-(2-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0011
-
-
 Cavia porcellus 1-(2-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0012
-
-
 Cavia porcellus 1-(3-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0012
-
-
 Cavia porcellus 1-benzyl-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.002
-
-
 Cavia porcellus 1-(4-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0024
-
-
 Cavia porcellus 1-(3-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
3.1.4.53 0.0034
-
-
 Cavia porcellus 1-(3-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione