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Literature summary extracted from

  • Aoki, J.; Inoue, A.; Makide, K.; Saiki, N.; Arai, H.
    Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family (2007), Biochimie, 89, 197-204.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.32 DNA and amino acid sequence analysis Rattus norvegicus
3.1.1.32 DNA and amino acid sequence analysis of isozymes, isozyme genetic structures, location of isozyme PS-PLA1 or PLA1A encoding gene on chromosome 3q13.2-q13.3, phylogenetic analysis of isozymes, overview Homo sapiens
3.1.1.32 DNA and amino acid sequence analysis of isozymes, location of isozyme PS-PLA1 or PLA1A encoding gene on chromosome 16 Mus musculus
3.1.1.32 phylogenetic tree, overview Cavia porcellus
3.1.1.32 phylogenetic tree, overview Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.32 additional information gene lpd encoding isozyme mPA-PLA1beta, i.e. the lipid defect locus lipase LPDL, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.32 extracellular
-
 Drosophila melanogaster
-
-
3.1.1.32 extracellular
-
 Bombyx mori
-
-
3.1.1.32 extracellular
-
 Dolichovespula maculata
-
-
3.1.1.32 extracellular isozyme PLA1S Cavia porcellus
-
-
3.1.1.32 extracellular isozyme PLA1S Mus musculus
-
-
3.1.1.32 extracellular isozyme PLA1S Homo sapiens
-
-
3.1.1.32 extracellular isozyme PLA1S Rattus norvegicus
-
-
3.1.1.32 membrane associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta Cavia porcellus 16020
-
3.1.1.32 membrane associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta Homo sapiens 16020
-
3.1.1.32 membrane associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta Rattus norvegicus 16020
-
3.1.1.32 membrane associated, phosphatidic acid-specific isozymes mPA-PLA1alpha or lipase H, and mPA-PLA1beta or lacrimal lipase Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.32 additional information Homo sapiens isozyme mPA-PLA1beta is identical to the lipid defect locus lipase LPDL, encoded by gene lpd, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis ?
-
 ?
3.1.1.32 additional information Mus musculus isozyme mPA-PLA1beta might plays a role in tumor progression ?
-
 ?
3.1.1.32 phosphatidylcholine + H2O Cavia porcellus
-
 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O Drosophila melanogaster
-
 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O Mus musculus
-
 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O Homo sapiens
-
 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O Rattus norvegicus
-
 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O Bombyx mori
-
 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O Dolichovespula maculata
-
 2-acylglycerophosphocholine + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.32 Bombyx mori
-
-
-
3.1.1.32 Cavia porcellus
-
 several isozymes
-
3.1.1.32 Dolichovespula maculata
-
 hornet
-
3.1.1.32 Drosophila melanogaster
-
-
-
3.1.1.32 Homo sapiens
-
 several isozymes
-
3.1.1.32 Mus musculus
-
 several isozymes
-
3.1.1.32 Rattus norvegicus
-
 several isozymes
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.32 phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate structure-function relationship Cavia porcellus
a
3.1.1.32 phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate structure-function relationship Drosophila melanogaster
a
3.1.1.32 phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate structure-function relationship Mus musculus
a
3.1.1.32 phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate structure-function relationship Homo sapiens
a
3.1.1.32 phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate structure-function relationship Rattus norvegicus
a
3.1.1.32 phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate structure-function relationship Bombyx mori
a
3.1.1.32 phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate structure-function relationship Dolichovespula maculata
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.32 blood platelet isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 blood platelet isozyme PS-PLA1 or PLA1A Rattus norvegicus
-
3.1.1.32 brain isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 colon isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 endothelium isozyme endothelial lipase Cavia porcellus
-
3.1.1.32 endothelium isozyme endothelial lipase Mus musculus
-
3.1.1.32 endothelium isozyme endothelial lipase Homo sapiens
-
3.1.1.32 endothelium isozyme endothelial lipase Rattus norvegicus
-
3.1.1.32 heart isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 heart isozyme PS-PLA1 or PLA1A Rattus norvegicus
-
3.1.1.32 kidney isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 liver isozyme hepatic lipase Cavia porcellus
-
3.1.1.32 liver isozyme hepatic lipase Mus musculus
-
3.1.1.32 liver isozyme hepatic lipase Homo sapiens
-
3.1.1.32 liver isozyme hepatic lipase Rattus norvegicus
-
3.1.1.32 lung isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 lung isozyme PS-PLA1 or PLA1A Rattus norvegicus
-
3.1.1.32 mast cell peritoneal, isozyme PS-PLA1 or PLA1A Rattus norvegicus
-
3.1.1.32 ovary isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 pancreas pancreatic lipase-related protein 2 Cavia porcellus
-
3.1.1.32 pancreas pancreatic lipase-related protein 2 Homo sapiens
-
3.1.1.32 pancreas pancreatic lipase-related protein 2 Rattus norvegicus
-
3.1.1.32 pancreas pancreatic lipase-related protein 2, isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 pancreatic acinar cell
-
 Homo sapiens
-
3.1.1.32 pancreatic juice
-
 Homo sapiens
-
3.1.1.32 plasma isozyme mPA-PLA1beta Homo sapiens
-
3.1.1.32 prostate isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 sperm isozyme mPA-PLA1beta Mus musculus
-
3.1.1.32 spleen isozyme mPA-PLA1alpha Mus musculus
-
3.1.1.32 testis isozyme mPA-PLA1alpha and isozyme mPA-PLA1beta Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.32 additional information isozyme mPA-PLA1beta is identical to the lipid defect locus lipase LPDL, encoded by gene lpd, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis Homo sapiens ?
-
 ?
3.1.1.32 additional information isozyme mPA-PLA1beta might plays a role in tumor progression Mus musculus ?
-
 ?
3.1.1.32 additional information several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity Cavia porcellus ?
-
 ?
3.1.1.32 additional information several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity Mus musculus ?
-
 ?
3.1.1.32 additional information several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity Homo sapiens ?
-
 ?
3.1.1.32 additional information several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity Rattus norvegicus ?
-
 ?
3.1.1.32 phosphatidic acid + H2O phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta Cavia porcellus ?
-
 ?
3.1.1.32 phosphatidic acid + H2O phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta Homo sapiens ?
-
 ?
3.1.1.32 phosphatidic acid + H2O phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta Rattus norvegicus ?
-
 ?
3.1.1.32 phosphatidic acid + H2O phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta Mus musculus 2-acyllysophosphatidic acid + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O
-
 Cavia porcellus 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O
-
 Drosophila melanogaster 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O
-
 Mus musculus 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O
-
 Homo sapiens 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O
-
 Rattus norvegicus 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O
-
 Bombyx mori 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylcholine + H2O
-
 Dolichovespula maculata 2-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.32 phosphatidylserine + H2O phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A Cavia porcellus ?
-
 ?
3.1.1.32 phosphatidylserine + H2O phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A Mus musculus ?
-
 ?
3.1.1.32 phosphatidylserine + H2O phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A Homo sapiens ?
-
 ?
3.1.1.32 phosphatidylserine + H2O phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.32 More amino acid sequence comparison Dolichovespula maculata
3.1.1.32 More isozyme tertiary structure analysis, amino acid sequence comparison Homo sapiens
3.1.1.32 More isozyme tertiary structure analysis, amino acid sequence comparison, overview Cavia porcellus
3.1.1.32 More isozyme tertiary structure analysis, overview Drosophila melanogaster
3.1.1.32 More isozyme tertiary structure analysis, overview Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.1.32 endothelial lipase
-
 Cavia porcellus
3.1.1.32 endothelial lipase
-
 Mus musculus
3.1.1.32 endothelial lipase
-
 Homo sapiens
3.1.1.32 endothelial lipase
-
 Rattus norvegicus
3.1.1.32 hepatic lipase
-
 Cavia porcellus
3.1.1.32 hepatic lipase
-
 Mus musculus
3.1.1.32 hepatic lipase
-
 Homo sapiens
3.1.1.32 hepatic lipase
-
 Rattus norvegicus
3.1.1.32 lacrimal lipase
-
 Mus musculus
3.1.1.32 lipase H
-
 Mus musculus
3.1.1.32 More the enzyme belongs to the pancreatic lipase gene family Drosophila melanogaster
3.1.1.32 More the enzyme belongs to the pancreatic lipase gene family Bombyx mori
3.1.1.32 More the enzyme belongs to the pancreatic lipase gene family Dolichovespula maculata
3.1.1.32 More the isozymes belong to the pancreatic lipase gene family or to the phospholipase family Cavia porcellus
3.1.1.32 More the isozymes belong to the pancreatic lipase gene family or to the phospholipase family Mus musculus
3.1.1.32 More the isozymes belong to the pancreatic lipase gene family or to the phospholipase family Homo sapiens
3.1.1.32 More the isozymes belong to the pancreatic lipase gene family or to the phospholipase family Rattus norvegicus
3.1.1.32 mPA-PLA1alpha
-
 Cavia porcellus
3.1.1.32 mPA-PLA1alpha
-
 Mus musculus
3.1.1.32 mPA-PLA1alpha
-
 Homo sapiens
3.1.1.32 mPA-PLA1alpha
-
 Rattus norvegicus
3.1.1.32 mPA-PLA1beta
-
 Cavia porcellus
3.1.1.32 mPA-PLA1beta
-
 Mus musculus
3.1.1.32 mPA-PLA1beta
-
 Homo sapiens
3.1.1.32 mPA-PLA1beta
-
 Rattus norvegicus
3.1.1.32 pancreatic lipase-related protein 2
-
 Cavia porcellus
3.1.1.32 pancreatic lipase-related protein 2
-
 Mus musculus
3.1.1.32 pancreatic lipase-related protein 2
-
 Homo sapiens
3.1.1.32 pancreatic lipase-related protein 2
-
 Rattus norvegicus
3.1.1.32 PLA1
-
 Cavia porcellus
3.1.1.32 PLA1
-
 Drosophila melanogaster
3.1.1.32 PLA1
-
 Mus musculus
3.1.1.32 PLA1
-
 Homo sapiens
3.1.1.32 PLA1
-
 Rattus norvegicus
3.1.1.32 PLA1
-
 Bombyx mori
3.1.1.32 PLA1
-
 Dolichovespula maculata
3.1.1.32 PLA1S
-
 Cavia porcellus
3.1.1.32 PLA1S
-
 Mus musculus
3.1.1.32 PLA1S
-
 Homo sapiens
3.1.1.32 PLA1S
-
 Rattus norvegicus
3.1.1.32 PLRP2
-
 Cavia porcellus
3.1.1.32 PLRP2
-
 Mus musculus
3.1.1.32 PLRP2
-
 Homo sapiens
3.1.1.32 PLRP2
-
 Rattus norvegicus