EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.17 | lipopolysaccharide | expression and activity of isoforms PDE2, PDE3, PDE11 in cultured peritoneal macrophages are recovered after treatment of cultured cells with lipopolysaccharide. Lipopolysaccharide also up-regulates enzyme expression in resident peritoneal macrophages | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.17 | cytoplasm | isoforms PDE1, PDE2,PDE3, PDE10, PDE11 | Rattus norvegicus | 5737 | - |
3.1.4.17 | membrane | isoforms PDE2,PDE3, PDE10, PDE11 | Rattus norvegicus | 16020 | - |
3.1.4.35 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.17 | Rattus norvegicus | - |
isoforms PDE1, PDE2, PDE3, PDE10, PDe11 | - |
3.1.4.35 | Rattus norvegicus | - |
isoform PDE5 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.17 | peritoneal macrophage | in freshly isolated peritoneal exudate macrophage, isoforms PDE1, PDE2, PDE3, PDE10, PDE11 are expressed. After 24h of cultures, levels of isoforms PDE2, PDE3, and PDE11 are markedly decreased. Their expression and activity are recovered after treatment of cultured cells with lipopolysaccharide | Rattus norvegicus | - |
3.1.4.35 | peritoneal macrophage | in freshly isolated peritoneal exudate macrophage, isoform PDE5 is expressed. After 24h of cultures, PDE5 is no longer present | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.35 | cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? |