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Literature summary extracted from

  • Witwicka, H.; Kobialka, M.; Siednienko, J.; Mitkiewicz, M.; Gorczyca, W.A.
    Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages (2007), Biochim. Biophys. Acta, 1773, 209-218.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.17 lipopolysaccharide expression and activity of isoforms PDE2, PDE3, PDE11 in cultured peritoneal macrophages are recovered after treatment of cultured cells with lipopolysaccharide. Lipopolysaccharide also up-regulates enzyme expression in resident peritoneal macrophages Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.17 cytoplasm isoforms PDE1, PDE2,PDE3, PDE10, PDE11 Rattus norvegicus 5737
-
3.1.4.17 membrane isoforms PDE2,PDE3, PDE10, PDE11 Rattus norvegicus 16020
-
3.1.4.35 cytoplasm
-
Rattus norvegicus 5737
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Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Rattus norvegicus
-
isoforms PDE1, PDE2, PDE3, PDE10, PDe11
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3.1.4.35 Rattus norvegicus
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isoform PDE5
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 peritoneal macrophage in freshly isolated peritoneal exudate macrophage, isoforms PDE1, PDE2, PDE3, PDE10, PDE11 are expressed. After 24h of cultures, levels of isoforms PDE2, PDE3, and PDE11 are markedly decreased. Their expression and activity are recovered after treatment of cultured cells with lipopolysaccharide Rattus norvegicus
-
3.1.4.35 peritoneal macrophage in freshly isolated peritoneal exudate macrophage, isoform PDE5 is expressed. After 24h of cultures, PDE5 is no longer present Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.35 cGMP + H2O
-
Rattus norvegicus 5'-GMP
-
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