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Literature summary extracted from

  • Duan, R.D.; Verkade, H.J.; Cheng, Y.; Havinga, R.; Nilsson, A.
    Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase (2007), Biochim. Biophys. Acta, 1771, 196-201.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 Bile salts required for enzyme activity, and probably to prevent enzyme dissociation from the membranes Rattus norvegicus
3.1.4.12 choline required for enzyme activity, and probably to prevent enzyme dissociation from the membranes Rattus norvegicus
3.1.4.12 taurocholate required for enzyme activity, and probably to prevent enzyme dissociation from the membranes Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information construction of nSMase2 knockout mice Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 additional information bile diversion reduces the alkaline SMase activity by 85% in the small intestinal content and 68% in the faeces, but not in the intestinal mucosa Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 membrane intestinal microvillar membrane Rattus norvegicus 16020
-
3.5.1.23 microvillar membrane
-
Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Mg2+ neutral SMase Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Rattus norvegicus the enzyme is involved in sphingomyelin digestion ?
-
?
3.5.1.23 additional information Rattus norvegicus neutral ceramidase is a key enzyme for hydrolysis of sphingomyelin in the gut ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Rattus norvegicus
-
healthy and permanently bile diverted male Wistar rats
-
3.5.1.23 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 gastrointestinal tract intraluminal, intestinal microvillar membrane, and mucosa, in the intestinal tract, the activity of alkaline SMase is much higher than the activity of neutral and acid SMase, overview Rattus norvegicus
-
3.5.1.23 intestine neutral ceramidase activities both in the intestinal mucosa and content are reduced by bile diversion. The presence of bile salts is important for maintaining high intraluminal levels of neutral ceramidase Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information the enzyme is involved in sphingomyelin digestion Rattus norvegicus ?
-
?
3.5.1.23 additional information neutral ceramidase is a key enzyme for hydrolysis of sphingomyelin in the gut Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid SMase
-
Rattus norvegicus
3.1.4.12 acid sphingomyelinase
-
Rattus norvegicus
3.1.4.12 alk-SMase
-
Rattus norvegicus
3.1.4.12 alkaline sphingomyelinase
-
Rattus norvegicus
3.1.4.12 intestinal sphingomyelinase
-
Rattus norvegicus
3.1.4.12 neutral SMase
-
Rattus norvegicus
3.1.4.12 neutral sphingomyelinase
-
Rattus norvegicus
3.5.1.23 N-CDase
-
Rattus norvegicus
3.5.1.23 neutral ceramidase
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 5
-
assay at, acid SMase Rattus norvegicus
3.1.4.12 7.5
-
assay at, neutral SMase Rattus norvegicus
3.1.4.12 9
-
assay at, alkaline SMase Rattus norvegicus