EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | Bile salts | required for enzyme activity, and probably to prevent enzyme dissociation from the membranes | Rattus norvegicus | |
3.1.4.12 | choline | required for enzyme activity, and probably to prevent enzyme dissociation from the membranes | Rattus norvegicus | |
3.1.4.12 | taurocholate | required for enzyme activity, and probably to prevent enzyme dissociation from the membranes | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.4.12 | additional information | construction of nSMase2 knockout mice | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | additional information | bile diversion reduces the alkaline SMase activity by 85% in the small intestinal content and 68% in the faeces, but not in the intestinal mucosa | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.12 | membrane | intestinal microvillar membrane | Rattus norvegicus | 16020 | - |
3.5.1.23 | microvillar membrane | - |
Rattus norvegicus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | Mg2+ | neutral SMase | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | additional information | Rattus norvegicus | the enzyme is involved in sphingomyelin digestion | ? | - |
? | |
3.5.1.23 | additional information | Rattus norvegicus | neutral ceramidase is a key enzyme for hydrolysis of sphingomyelin in the gut | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Rattus norvegicus | - |
healthy and permanently bile diverted male Wistar rats | - |
3.5.1.23 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | gastrointestinal tract | intraluminal, intestinal microvillar membrane, and mucosa, in the intestinal tract, the activity of alkaline SMase is much higher than the activity of neutral and acid SMase, overview | Rattus norvegicus | - |
3.5.1.23 | intestine | neutral ceramidase activities both in the intestinal mucosa and content are reduced by bile diversion. The presence of bile salts is important for maintaining high intraluminal levels of neutral ceramidase | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | additional information | the enzyme is involved in sphingomyelin digestion | Rattus norvegicus | ? | - |
? | |
3.5.1.23 | additional information | neutral ceramidase is a key enzyme for hydrolysis of sphingomyelin in the gut | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | acid SMase | - |
Rattus norvegicus |
3.1.4.12 | acid sphingomyelinase | - |
Rattus norvegicus |
3.1.4.12 | alk-SMase | - |
Rattus norvegicus |
3.1.4.12 | alkaline sphingomyelinase | - |
Rattus norvegicus |
3.1.4.12 | intestinal sphingomyelinase | - |
Rattus norvegicus |
3.1.4.12 | neutral SMase | - |
Rattus norvegicus |
3.1.4.12 | neutral sphingomyelinase | - |
Rattus norvegicus |
3.5.1.23 | N-CDase | - |
Rattus norvegicus |
3.5.1.23 | neutral ceramidase | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 5 | - |
assay at, acid SMase | Rattus norvegicus |
3.1.4.12 | 7.5 | - |
assay at, neutral SMase | Rattus norvegicus |
3.1.4.12 | 9 | - |
assay at, alkaline SMase | Rattus norvegicus |