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Literature summary extracted from
- A versatile equation to describe reversible enzyme inhibition and activation kinetics: modeling beta-galactosidase and butyrylcholinesterase (2007), Biochim. Biophys. Acta, 1770, 733-746.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.8 | Butyrylcholine | substrate activation, overview | Homo sapiens |  |
| 3.1.1.8 | homocysteine thiolactone | non-substrate activation | Homo sapiens | |
| 3.1.1.8 | additional information | activation kinetics and modelling | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.8 | galantamine | slight reversible inhibition | Homo sapiens | |
| 3.2.1.23 | imidazole | inhibition mechanism and kinetics, modeling, overview | Kluyveromyces lactis | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.8 | additional information | - |
additional information | kinetics and kinetic modelling, the enzyme does not show typical Michaelis-Menten kinetics due to substrate activation at higher butyrylcholine concentration, overview | Homo sapiens | |
| 3.2.1.23 | additional information | - |
additional information | detailed kinetics, overview | Kluyveromyces lactis |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.8 | extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.8 | butyrylthiocholine + H2O | Homo sapiens | - |
thiocholine + butyrate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.8 | Homo sapiens | - |
- |
- |
| 3.2.1.23 | Kluyveromyces lactis | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.8 | blood plasma | - |
Homo sapiens | - |
| 3.2.1.23 | commercial preparation | - |
Kluyveromyces lactis | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.8 | butyrylthiocholine + H2O | - |
Homo sapiens | thiocholine + butyrate | - |
? | |
| 3.2.1.23 | 2-nitrophenyl beta-D-galactopyranoside + H2O | - |
Kluyveromyces lactis | 2-nitrophenol + beta-D-galactose | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.8 | BuChE | - |
Homo sapiens |
| 3.1.1.8 | butyrylcholinesterase | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.8 | 22 | - |
assay at | Homo sapiens |
| 3.2.1.23 | 22 | - |
assay at | Kluyveromyces lactis |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.8 | 8 | - |
assay at | Homo sapiens |
| 3.2.1.23 | 7.5 | - |
assay at | Kluyveromyces lactis |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.8 | additional information | - |
additional information | inhibition kinetics and modelling | Homo sapiens | |
| 3.2.1.23 | additional information | - |
additional information | detailed inhibition kinetics, overview | Kluyveromyces lactis |
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