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Literature summary extracted from
- Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs (2006), Biochim. Biophys. Acta, 1760, 1080-1087.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.33 | expressed in Escherichia coli BL21(DE3) cells | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.33 | 2-fluoromevalonate 5-diphosphate | irreversible inhibitor | Rattus norvegicus |  |
| 4.1.1.33 | geranyl diphosphate | - |
Rattus norvegicus | |
| 4.1.1.33 | P'-geranyl 2-fluoromevalonate 5-diphosphate | irreversible inhibitor | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.33 | 0.00053 | - |
ATP | - |
Rattus norvegicus | |
| 4.1.1.33 | 0.036 | - |
5-diphosphomevalonate | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.1.1.33 | peroxisome | - |
Rattus norvegicus | 5777 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.33 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.33 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.33 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.33 | ATP + 5-diphosphomevalonate | - |
Rattus norvegicus | ADP + phosphate + isopentenyl diphosphate + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.33 | MDD | - |
Rattus norvegicus |
| 4.1.1.33 | Mevalonate 5-diphosphate decarboxylase | - |
Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.33 | 0.00302 | - |
2-fluoromevalonate 5-diphosphate | in 100 mM Tris buffer, pH 7.5, at 25°C | Rattus norvegicus | |
| 4.1.1.33 | 0.0046 | - |
P'-geranyl 2-fluoromevalonate 5-diphosphate | in 100 mM Tris buffer, pH 7.5, at 25°C | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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