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Literature summary extracted from

  • Hall, R.S.; Brown, S.; Fedorov, A.A.; Fedorov, E.V.; Xu, C.; Babbitt, P.C.; Almo, S.C.; Raushel, F.M.
    Structural diversity within the mononuclear and binuclear active sites of N-acetyl-D-glucosamine-6-phosphate deacetylase (2007), Biochemistry, 46, 7953-7962.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.25
-
 Escherichia coli
3.5.1.25 expression in Escherichia coli Thermotoga maritima

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.1.25
-
 Thermotoga maritima
3.5.1.25
-
 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.25 N-methylhydroxyphosphinyl-D-glucosamine 6-phosphate
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.25 0.04
-
 N-acetyl-D-glucosamine 6-phosphate
-
 Thermotoga maritima

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.25 Zn binding to the active site Escherichia coli
3.5.1.25 Zn binding to the active site, one cation per subunit Thermotoga maritima

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.25 N-acetyl-D-glucosamine-6-phosphate + H2O Thermotoga maritima
-
 D-glucosamine 6-phosphate + acetate
-
 ?
3.5.1.25 N-acetyl-D-glucosamine-6-phosphate + H2O Escherichia coli
-
 D-glucosamine 6-phosphate + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.25 Escherichia coli P0AF18
-
-
3.5.1.25 Thermotoga maritima
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.25
-
 Escherichia coli
3.5.1.25 size exclusion column and anion exchange column Thermotoga maritima

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.25 N-acetyl-D-glucosamine-6-phosphate + H2O
-
 Thermotoga maritima D-glucosamine 6-phosphate + acetate
-
 ?
3.5.1.25 N-acetyl-D-glucosamine-6-phosphate + H2O
-
 Escherichia coli D-glucosamine 6-phosphate + acetate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.1.25 homotetramer determined by gel filtration chromatography, SAXS and analytical ultracentrifugation, dimer of dimers Thermotoga maritima

Synonyms

EC Number Synonyms Comment Organism
3.5.1.25 N-acetyl-D-glucosamine-6-phosphate deacetylase
-
 Thermotoga maritima
3.5.1.25 N-acetyl-D-glucosamine-6-phosphate deacetylase
-
 Escherichia coli
3.5.1.25 NagA
-
 Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.1.25 110
-
 N-acetyl-D-glucosamine 6-phosphate
-
 Thermotoga maritima