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Literature summary extracted from

  • Raboni, S.; Mozzarelli, A.; Cook, P.F.
    Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium (2007), Biochemistry, 46, 13223-13234.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.20 0.14
-
L-serine in the presence of 250 mM NaCl, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 0.27
-
L-serine in the presence of 100 mM KCl, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 0.52
-
L-serine in the presence of 250 mM NaCl, at pH 7.8 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 0.58
-
L-serine in the presence of 100 mM KCl, at pH 7.8 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 1.6
-
L-serine without monovalent cations, at pH 6.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 1.6
-
L-serine without monovalent cations, at pH 7.8 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 1.89
-
L-serine in the presence of 100 mM KCl, at pH 6.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 1.9
-
L-serine in the presence of 100 mM CsCl, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 2.7
-
L-serine without monovalent cations, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 4.78
-
L-serine in the presence of 250 mM NaCl, at pH 6.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 5.6
-
L-serine in the presence of 100 mM CsCl, at pH 7.8 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 9
-
L-serine in the presence of 100 mM CsCl, at pH 6.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.20 Cs+ stimulates activity at 100 mM Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 K+ stimulates activity at 100 mM Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 Na+ stimulates activity at 250 mM Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.20 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.20 L-serine + indole
-
Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + H2O
-
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Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.20 additional information
-
L-serine in the presence of 100 mM CsCl, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 0.24
-
L-serine without monovalent cations, at pH 6.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 0.91
-
L-serine without monovalent cations, at pH 7.8 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 1.37
-
L-serine without monovalent cations, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 1.9
-
L-serine in the presence of 250 mM NaCl, at pH 6.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 1.9
-
L-serine in the presence of 250 mM NaCl, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 2.08
-
L-serine in the presence of 100 mM KCl, at pH 6.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 2.8
-
L-serine in the presence of 250 mM NaCl, at pH 7.8 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 4
-
L-serine in the presence of 100 mM KCl, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 4.8
-
L-serine in the presence of 100 mM KCl, at pH 7.8 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 6
-
L-serine in the presence of 100 mM CsCl, at pH 6.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 6.15
-
L-serine in the presence of 100 mM CsCl, at pH 8.5 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 8.7
-
L-serine in the presence of 100 mM CsCl, at pH 7.8 and 25°C Salmonella enterica subsp. enterica serovar Typhimurium

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.2.1.20 6 10
-
Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.20 pyridoxal 5'-phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium