Literature summary extracted from
Pearce, F.G.; Perugini, M.A.; McKerchar, H.J.; Gerrard, J.A.
Dihydrodipicolinate synthase from Thermotoga maritima (2006), Biochem. J., 400, 359-366.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
4.3.3.7 |
- |
Thermotoga maritima |
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
4.3.3.7 |
the X-ray crystal structure is described |
Thermotoga maritima |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
4.3.3.7 |
additional information |
not inhibited by (S)-lysine, suggesting that feedback control of the lysine biosynthetic pathway evolves later in the bacterial lineage |
Thermotoga maritima |
|
Molecular Weight [Da]
EC Number |
Molecular Weight [Da] |
Molecular Weight Maximum [Da] |
Comment |
Organism |
---|
4.3.3.7 |
33800 |
- |
4 * 33800, calculated from sequence |
Thermotoga maritima |
4.3.3.7 |
133000 |
- |
sedimentation equilibrium analysis |
Thermotoga maritima |
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
4.3.3.7 |
(S)-aspartate 4-semialdehyde + pyruvate |
Thermotoga maritima |
catalyses the branch point in lysine biosynthesis |
dihydrodipicolinate + H2O |
- |
? |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
4.3.3.7 |
Thermotoga maritima |
Q9X1K9 |
- |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
4.3.3.7 |
- |
Thermotoga maritima |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
4.3.3.7 |
(S)-aspartate 4-semialdehyde + pyruvate |
catalyses the branch point in lysine biosynthesis |
Thermotoga maritima |
dihydrodipicolinate + H2O |
- |
? |
|
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
4.3.3.7 |
tetramer |
4 * 33800, calculated from sequence |
Thermotoga maritima |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
4.3.3.7 |
DHDPS |
- |
Thermotoga maritima |
Temperature Stability [°C]
EC Number |
Temperature Stability Minimum [°C] |
Temperature Stability Maximum [°C] |
Comment |
Organism |
---|
4.3.3.7 |
90 |
- |
7 h, 40% loss of activity. When the enzyme is incubated at 90°C in 8M urea, 60% of the activity is lost after 90 min |
Thermotoga maritima |