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Literature summary extracted from

  • Kasuya, F.; Igarashi, K.; Fukui, M.; Nokihara, K.
    Purification and characterization of a medium chain acyl-coenzyme A synthetase (1996), Drug Metab. Dispos., 24, 879-883.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.2.1.2 bovine serum albumin
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.2 iodoacetamide
-
 Bos taurus
6.2.1.2 salicylic acid
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.2 mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.2 ATP + a medium chain fatty acid or an aromatic acid or an arylacetic acid + CoA Bos taurus the enzyme catalyzes the first reaction of glycine conjugation, which is an important route of detoxification of many xenobiotic and endogenous carboxylic acids ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.2 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.2.1.2 3.718
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.2 ATP + a medium chain fatty acid or an aromatic acid or an arylacetic acid + CoA the enzyme catalyzes the first reaction of glycine conjugation, which is an important route of detoxification of many xenobiotic and endogenous carboxylic acids Bos taurus ?
-
 ?
6.2.1.2 ATP + benzoic acid + CoA also active with several benzoic acids substituted at position 2, 3 or 4 Bos taurus AMP + diphosphate + benzoyl-CoA
-
 ?
6.2.1.2 ATP + dodecanoate + CoA
-
 Bos taurus AMP + diphosphate + dodecanoyl-CoA
-
 ?
6.2.1.2 ATP + heptanoate + CoA
-
 Bos taurus AMP + diphosphate + heptanoyl-CoA
-
 ?
6.2.1.2 ATP + hexanoate + CoA highest activity Bos taurus AMP + diphosphate + hexanoyl-CoA
-
 ?
6.2.1.2 ATP + octanoate + CoA
-
 Bos taurus AMP + diphosphate + octanoyl-CoA
-
 ?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.2.1.2 8.5 10 8.5: 53% of maximal activity, 10.0: 80% of maximal activity, a pH-optimum is not observed Bos taurus