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Literature summary extracted from

  • Yakovlev, G.I.; Mitkevich, V.A.; Struminskaya, N.K.; Varlamov, V.P.; Makarov, A.A.
    Low molecular weight chitosan is an efficient inhibitor of ribonucleases (2007), Biochem. Biophys. Res. Commun., 357, 584-588.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.6.1.24 medicine RNase inhibitors appear to be promising for therapy of cancer Bos taurus
4.6.1.24 medicine RNase inhibitors appear to be promising for therapy of cancer Bacillus amyloliquefaciens
4.6.1.24 medicine RNase inhibitors appear to be promising for therapy of cancer Kitasatospora aureofaciens
4.6.1.24 medicine RNase inhibitors appear to be promising for therapy of cancer Aspergillus oryzae
4.6.1.24 medicine RNase inhibitors appear to be promising for therapy of cancer Bacillus intermedius
4.6.1.24 medicine RNase inhibitors appear to be promising for therapy of cancer Penicillium brevicompactum

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.18 chitosan molecular weight about 6 kDA, complex formation with enzyme due to establishment of 5-6 ion pairs Bos taurus
4.6.1.18 additional information not inhibitory: monoglucosamine up to 2 mM Bos taurus
4.6.1.24 chitosan
-
 Aspergillus oryzae
4.6.1.24 chitosan
-
 Bacillus amyloliquefaciens
4.6.1.24 chitosan
-
 Bacillus intermedius
4.6.1.24 chitosan
-
 Bos taurus
4.6.1.24 chitosan
-
 Kitasatospora aureofaciens
4.6.1.24 chitosan
-
 Penicillium brevicompactum

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Bos taurus
-
 Type XII A, commercial product, Sigma
-
4.6.1.24 Aspergillus oryzae
-
-
-
4.6.1.24 Bacillus amyloliquefaciens
-
-
-
4.6.1.24 Bacillus intermedius
-
-
-
4.6.1.24 Bos taurus
-
-
-
4.6.1.24 Kitasatospora aureofaciens
-
-
-
4.6.1.24 Penicillium brevicompactum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.24
-
 Bacillus amyloliquefaciens
4.6.1.24
-
 Kitasatospora aureofaciens
4.6.1.24
-
 Bacillus intermedius
4.6.1.24
-
 Penicillium brevicompactum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.24 pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 poly(C) + H2O
-
 Bos taurus 3'-CMP + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 poly(I)poly(C) + H2O
-
 Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.24 barnase
-
 Bacillus amyloliquefaciens
4.6.1.24 Binase
-
 Bacillus intermedius
4.6.1.24 ribonuclease
-
 Bacillus amyloliquefaciens
4.6.1.24 ribonuclease
-
 Bacillus intermedius
4.6.1.24 ribonuclease A
-
 Bos taurus
4.6.1.24 ribonuclease Pb2
-
 Penicillium brevicompactum
4.6.1.24 Ribonuclease SA
-
 Kitasatospora aureofaciens
4.6.1.24 ribonuclease T1
-
 Aspergillus oryzae
4.6.1.24 RNase A
-
 Bos taurus
4.6.1.24 RNase Pb2
-
 Penicillium brevicompactum
4.6.1.24 RNase Sa
-
 Kitasatospora aureofaciens
4.6.1.24 RNase T1
-
 Aspergillus oryzae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.6.1.18 0.00021
-
 chitosan substrate poly(I)poly(C), pH 7.0, 25°C Bos taurus
4.6.1.18 0.00022
-
 chitosan substrate poly(C), pH 7.0, 25°C Bos taurus
4.6.1.24 0.000033
-
 chitosan poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA Kitasatospora aureofaciens
4.6.1.24 0.00008
-
 chitosan poly(A) * poly(U) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA Penicillium brevicompactum
4.6.1.24 0.00009
-
 chitosan poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA Penicillium brevicompactum
4.6.1.24 0.0001
-
 chitosan poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA Bacillus intermedius
4.6.1.24 0.00012
-
 chitosan poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA Bacillus amyloliquefaciens
4.6.1.24 0.00012
-
 chitosan poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA Aspergillus oryzae
4.6.1.24 0.00021
-
 chitosan poly(I) * poly(C) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA Bos taurus
4.6.1.24 0.00022
-
 chitosan poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA Bos taurus