Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gilbert, S.J.; Blain, E.J.; Jones, P.; Duance, V.C.; Mason, D.J.
    Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: An in vitro study (2006), Arthritis Res. Ther., 8, R89.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 quantitative expression analysis of acidic SMase in articular chondrocytes, overview Bos taurus
3.1.4.12 quantitative expression analysis of neutral SMase in articular chondrocytes, overview Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 ceramide product feedback inhibition; product feedback inhibition Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Bos taurus exogenous sphingomyelinase increases collagen and sulfated glycosaminoglycan production by primary articular chondrocytes, phenotype, overview ?
-
 ?
3.1.4.12 sphingomyelin + H2O Bos taurus the enzyme is important in the ceramide catabolism, overview N-acylsphingosine + choline phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Bos taurus
-
-
-
3.1.4.12 Bos taurus Q9BDR3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 cartilage
-
 Bos taurus
-
3.1.4.12 chondrocyte articular Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.12 additional information
-
 quantitative expression analysis in articular chondrocytes Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information exogenous sphingomyelinase increases collagen and sulfated glycosaminoglycan production by primary articular chondrocytes, phenotype, overview Bos taurus ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Bos taurus N-acylsphingosine + choline phosphate
-
 ir
3.1.4.12 sphingomyelin + H2O the enzyme is important in the ceramide catabolism, overview Bos taurus N-acylsphingosine + choline phosphate
-
 ir

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acidic SMase
-
 Bos taurus
3.1.4.12 neutral SMase
-
 Bos taurus
3.1.4.12 sphingomyelinase
-
 Bos taurus