EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.4.12 | additional information | downregulation of N-SMase2 by siRNA leads to inhibition of TNFalpha-induced activation of endothelial nitric oxide synthase in the sphingomyelin and ceramide metabolism, overview | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | additional information | Homo sapiens | neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors are essentially involved in endothelial nitric oxide synthase activation by tumor necrosis factor alpha, regulation of the pathway, overview | ? | - |
? | |
3.1.4.12 | sphingomyelin + H2O | Homo sapiens | - |
N-acylsphingosine + choline phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | endothelial cell | - |
Homo sapiens | - |
3.1.4.12 | endothelium | - |
Homo sapiens | - |
3.1.4.12 | HeLa cell | - |
Homo sapiens | - |
3.1.4.12 | umbilical vein endothelial cell | i.e. HUVEC | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | additional information | neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors are essentially involved in endothelial nitric oxide synthase activation by tumor necrosis factor alpha, regulation of the pathway, overview | Homo sapiens | ? | - |
? | |
3.1.4.12 | sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | N-SMase2 | - |
Homo sapiens |
3.1.4.12 | neutral sphingomyelinase 2 | - |
Homo sapiens |