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Literature summary extracted from
- 1H-Benzimidazole derivatives as mammalian DNA topoisomerase I inhibitors (2007), Acta Biochim. Pol., 54, 561-565.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 5.6.2.1 | drug development | topoisomerase poisoning has been recognized as an effective approach for the development of chemotherapeutics | Mammalia |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.2.1 | 4-(1H-benzimidazole-2-yl)phenol | Cpd III, 1H-benzimidazole derivative | Mammalia |  |
| 5.6.2.1 | 5-chloro-4-(1H-benzimidazole-2-yl)phenol | Cpd I, 1H-benzimidazole derivative | Mammalia | |
| 5.6.2.1 | 5-methyl-4-(1H-benzimidazole-2-yl)phenol | Cpd II, 1H-benzimidazole derivative | Mammalia | |
| 5.6.2.1 | camptothecin | inhibitor of topoisomerase I | Mammalia | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | Mammalia | - |
- |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.6.2.1 | DNA topoisomerase I | - |
Mammalia |
| 5.6.2.1 | Topo I | - |
Mammalia |
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