EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.5 | glycyrrhizic acid | slightly activates isozyme NAT1 | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.5 | drug development | inhibitors of NAT enzymes may be valuable as chemopreventive agents | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.5 | (-)-epigallocatechin-3-O-gallate | EGCG, non-competitive | Homo sapiens | |
2.3.1.5 | caffeic acid | non-competitive | Homo sapiens | |
2.3.1.5 | curcumin | non-competitive | Homo sapiens | |
2.3.1.5 | esculetin | - |
Homo sapiens | |
2.3.1.5 | ferulic acid | - |
Homo sapiens | |
2.3.1.5 | gallic acid | - |
Homo sapiens | |
2.3.1.5 | genistein | - |
Homo sapiens | |
2.3.1.5 | kaemferol | non-competitive; non-competitive | Homo sapiens | |
2.3.1.5 | additional information | inhibitory potency of flavonoids on isozyme NAT1, no inhibition by curcumin, silymarin, and scopoletin, overview; inhibitory potency of flavonoids on isozyme NAT2, no inhibition by ()epigallocatechin gallate, gallic acid, caffeic acid, and ferulic acid, overview | Homo sapiens | |
2.3.1.5 | quercetin | non-competitive; non-competitive | Homo sapiens | |
2.3.1.5 | scopoletin | - |
Homo sapiens | |
2.3.1.5 | silymarin | - |
Homo sapiens | |
2.3.1.5 | taxifolin | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.5 | additional information | - |
additional information | kinetics | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.5 | cytosol | isozyme NAT1 | Homo sapiens | 5829 | - |
2.3.1.5 | cytosol | isozyme NAT2 | Homo sapiens | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.5 | acetyl-CoA + an arylamine | Homo sapiens | NATs are important enzymes involved in the metabolic activation of aromatic and heterocyclic amines | CoA + an N-acetylarylamine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.5 | Homo sapiens | P11245 | isozyme NAT2; isozyme NAT2 | - |
2.3.1.5 | Homo sapiens | P18440 | isozyme NAT1; isozyme NAT1 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.5 | native enzyme partially by subcellular fractionation | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.5 | cholangiocarcinoma cell | isozyme NAT1 | Homo sapiens | - |
2.3.1.5 | KMBC cell | a cholangiocarcinoma cell line, isozyme NAT1 | Homo sapiens | - |
2.3.1.5 | liver | isozyme NAT1 | Homo sapiens | - |
2.3.1.5 | liver | isozyme NAT2 | Homo sapiens | - |
2.3.1.5 | additional information | no isozyme NAT2 activity in cholangiocarcinoma cells | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.5 | acetyl-CoA + 4-aminobenzoic acid | isozyme NAT1 | Homo sapiens | CoA + N-acetyl-4-aminobenzoic acid | - |
? | |
2.3.1.5 | acetyl-CoA + an arylamine | - |
Homo sapiens | CoA + an N-acetylarylamine | - |
? | |
2.3.1.5 | acetyl-CoA + an arylamine | NATs are important enzymes involved in the metabolic activation of aromatic and heterocyclic amines | Homo sapiens | CoA + an N-acetylarylamine | - |
? | |
2.3.1.5 | acetyl-CoA + sulfamethazine | isozyme NAT2 | Homo sapiens | CoA + N-acetyl-sulfamethazine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.5 | NAT | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.5 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.5 | 7.5 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.5 | acetyl-CoA | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.5 | additional information | - |
additional information | inhibition kinetics, isozyme NAT1 | Homo sapiens | |
2.3.1.5 | additional information | - |
additional information | inhibition kinetics, isozyme NAT2 | Homo sapiens | |
2.3.1.5 | 0.01 | - |
quercetin | isozyme NAT2 | Homo sapiens | |
2.3.1.5 | 0.0486 | - |
quercetin | isozyme NAT1 | Homo sapiens |